ID A0A1L8GM91_XENLA Unreviewed; 730 AA.
AC A0A1L8GM91;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN Name=kif2c.L {ECO:0000313|RefSeq:XP_018113838.1,
GN ECO:0000313|Xenbase:XB-GENE-17344777};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018113838.1};
RN [1] {ECO:0000313|RefSeq:XP_018113838.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018113838.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018113838.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR RefSeq; XP_018113838.1; XM_018258349.2.
DR AlphaFoldDB; A0A1L8GM91; -.
DR STRING; 8355.A0A1L8GM91; -.
DR PaxDb; 8355-A0A1L8GM91; -.
DR GeneID; 108714276; -.
DR KEGG; xla:108714276; -.
DR AGR; Xenbase:XB-GENE-17344777; -.
DR CTD; 108714276; -.
DR Xenbase; XB-GENE-17344777; kif2c.L.
DR OMA; RTTLECH; -.
DR OrthoDB; 239968at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 108714276; Expressed in egg cell and 18 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01367; KISc_KIF2_like; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47971:SF19; KINESIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR47971; KINESIN-RELATED PROTEIN 6; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT BINDING 353..360
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 730 AA; 82727 MW; 393D069531309654 CRC64;
MERLLANRLF TGLAVKIMRS NGVIHNANIT SVNMDRSSVN VEWKEGEASK GKEISFADVI
SVNPELLDAV LVPPNVKENM PTQRIVSSQN HKRKTISKIP APKEVTTKNS TLPECGTQSV
LRERSTRMTA IHETLPSENE MEVESTPLPI QQNSIQVARS RSTKASVAGE PRLQLRISEI
VEESLPSVKN NQARRKSNIV KEIEKMKSKR EEQRAQNTEL RIKRAQDYDT SVPNWQFGKM
IKEFRATMDC HRISMADPAE EHRICVCVRK RPLNKQELSK KEIDIISVPS KNIVLVHEPK
LKVDLTKYLE NQAFRFDFSF DETATNEVVY RFTARPLVQS IFEGGKATCF AYGQTGSGKT
HTMGGDFSGK SQNVSKGVYA FASRDVFLLL DQPRYRHLDL EVFVTFFEIY NGKVFDLLNK
KTKLRVLEDA KQEVQVVGLL EKQVTSADDV FKMIEIGSAC RTSGQTFANT SSSRSHACLQ
IILRRGRKLH GKFSLVDLAG NERGADTASA DRITRMEGAE INRSLLALKE CIRALGQNKS
HTPFRESKLT QILRDSFIGE NSRTCMIAML SPGFNSCEYT LNTLRYADRV KELSPQNAET
NDDNLQMDTE DSDESHASIG GLELQDDKDE ELSTHNSFQD ALHRVGELED KAVDELRELV
QREPEWTNLL QMTEQPDYDL ENFVMQAEYL IQERSKVLIA LGDSINSLRL ALQVEERASK
QISKKRRFNK
//
