ID A0A1L8GN87_XENLA Unreviewed; 3886 AA.
AC A0A1L8GN87;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Abnormal spindle-like microcephaly-associated protein homolog isoform X3 {ECO:0000313|RefSeq:XP_018114143.1};
GN Name=aspm.L {ECO:0000313|Xenbase:XB-GENE-6485866};
GN Synonyms=LOC108714434 {ECO:0000313|RefSeq:XP_018114143.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018114143.1};
RN [1] {ECO:0000313|RefSeq:XP_018114143.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018114143.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018114143.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_018114143.1; XM_018258654.2.
DR STRING; 8355.A0A1L8GN87; -.
DR PaxDb; 8355-A0A1L8GN87; -.
DR GeneID; 108714434; -.
DR CTD; 108714434; -.
DR Xenbase; XB-GENE-6485866; aspm.L.
DR OMA; CCCCYIF; -.
DR OrthoDB; 53079at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 108714434; Expressed in blastula and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 38.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 39.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 81.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 18.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 52.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 917..1053
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1106..1257
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 493..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3886 AA; 453664 MW; C97245524A2325F2 CRC64;
MLRISPPGPA PKSPPDEPPL LSLTHFSRAP FVSFGCVRPG SVSSACLLLH NPNPEPASLA
VFKLPKNRGF SIVETETVIP PLETISLTIT WTPLEEGNVR EIVTFIVNDV VKHQAVLLGC
AELPVKKKRN TWSTIRMKNK PIGPKIPVRR QKEVEVTSKT RKLNVTKKDK HGQLESTRSP
LQSCENLARS LCTPSPMREI RLSTENRVPA LTISPVGNEL EPFAPGSLKR SKTYSVLCTV
EYNESTEVTT TSKYYTDVHV EEEWTLNAHK LNKQSMSPIN PMHSQNHNVT LTPDLMIESA
LNSIISPTAF CNQGPVQIDA CTSVHTEEEL TQERFNLASS KMPSPASPMV TPKRKFLSPN
SFLNNSFVPD EFFSADEHTP IISPEQFVRE NGLTSQSASS LNGPMLSNSC QLANQNLSTL
SSSSAIQDVQ ISGGPVEQEL SSPIMEPVLN SRLTYCVKKT KQLIKFAAEH DQNLVEEPEK
PCVLSATVTK LKAEDRKEKP TGQLPKSRRR LDNTTPEHKG SVTSSNIVLQ DLPVISVPCL
NYHSSAESYK RASKSLVLNR KRKSEEFLGT NKETELGTIP QFKKTHLSKP DFSNASNKEK
FSQRKPLVTQ LRISEKNLKT QNAAAKGKPT ILKAQSDYVG PPKQKVAVTF KNSKRVVAIP
QSKLVFTKTP KTVIPRHPMP FAAKNMFYDE RWMAKQERGF TWWLNFILTP DDFAVTRDSS
KVHAATLILG TENTHKVSVP RAPTKEEVSL KAYTTRCKLN RLRRSACRLF TSEPVVKAIL
RLEVEIEAQR LLVRRDRHLW KDIGERQKIL NWLLSYNPLW LRIGLETIFG ELISLESNSD
VTGLAVFILN RLLWNPDIAA EYRHPSVPHL YRDGHEEALS KFTLKKLLLL VFFLDHAKQS
RLIDHDPCLF WKDAEYKTSK DLLLSFSRDF LSGEGDLSRH LGYLGLPVSH VQTPLDEFDF
AVTNLAVDLQ CGVRLVRTVE LLAQNWSLSK KLRVPAISRL QKMHNVEVAL QALMERGVPL
KDERGASITS KDIVDRHRER TLALLWKIVF AFQVDVLLST KQLKEEIQVL KVSYSTQKQL
AALRSLSNPM TIQKRESDPF EPEKYSERVS LLMEWVNAVC RFYSTKVQNF TVSFSDGRVF
CYLVNHYHPS YLPLNAVSQR TTQTVECCQS GTAMLNSSSD SDNSLDVWPG VFDQGVTSSA
LYKELLENEQ TNFSLVHTAV ADLGGIPAMV HHSDMSNTIP DEKIVITFLS FLCARLLDLR
KETRAARVIQ TFWRNYRLKV EQKLLESKHK AACVIQRAVI RFLSRCRLQI RSCSAVVIQK
NFRRYLAQRQ LKELKALKHK ELQTKATVII QRFWRGYSAQ RRFIFLRHYV IRMQARVRAK
RAESSYKRIQ WATLTLQSHM HSWLLGKKER QKYLHMKSSI IIIQHAFKKW KSEKQKRHTE
AVLIIQKCYR RWKACKLIAQ NIAAVKIQSV YRMHRERQKF LDTKCKIIRI QSWFRCKRDR
KAFLIQRKNV LTLQQYYRAF KQGRLDRKTF LEMRSAAVCI QAHYRGMRVR QLYHRIKAAC
ILQSYWRMRQ QKKMYTHMKQ LVVLLQSNVR KYQQEKQFKG IKSAACVIQS YYRSHRATKL
AVHRFKQKRN AATVIQSAFR RMQARKANLQ VKSAVKIQAL YRSYVTRRKF VEMKAASIKI
QSAFRMRQRR VRYCALRKAT LFVQQKFRAK KQMQKQQDTY IKLQMACVKV QAAVRGNFVR
KEIQSWHKAA TVLQAQYRMW RQKKQYLLIY RAAIIIQEHY RAHKMQVHQR ANFLLIKHSA
IILQAAYRGY TLRKSIMIQR FAAIRIQTAF RSCRIRGNYL RIKQSVVTIQ RWYRCKTAGR
KERERFLCSQ RAIVTIQSAY RGWVTRKQVK VWNTAAVCVQ SAFRRYAAQK KIRTMTKAAL
NIQQRYRAVL ASRRERKRYL ELCIGVKKIQ ALWRGRTVRK DLERQHKSAA LIQSYYRMHV
CQIKYRAMKQ ASLLIQRLYR AHKLGQSQRY LYLSLKKSAT VLQSAYRGWK VRRQMQNLHN
AATTIQAAFR SFICQKRYNV LTTATITIQR HYRAFSRGRL QRTKYINVRK SVIVLQSAFR
SALVRKSILR MHQSAVVVQR NYRALLTGRK VRKQYLELHK ATCSLQAAWR GRTVRKDIER
QHKSAALIQS YYRMHVCQIK YRAMKQASLL IQQFYRAHKL GQSQRYLYLS LKKSATVLQS
AYRGWKVRRQ MQNLHNAATT IQAAFRSFIC QKRYNVLTTA TITIQRHYRA FSRGRLQRTK
YINVRKSAIV LQSAFRSALV RKSILRMHQS AVVVQRNYRA LLTGRKVRKQ YLELHKATCS
LQAAWRGRTV RKDLERQHNS AALIQSYYRM HVCQIKYRAM RQASLLIQRF YRAHKLGQSQ
RYLYLSLKKS AMVLQSAYRG WKVRRQMQNL HNAATTIQAA FRSFICQKRY NLLTTVTITI
QRHYRAFSCG RLQRAKYINV RKSAIVLQSA FRSALVQKRI WRMHQSAVVV QRNYRALLTG
RKVRKQYLEL HKATCTLQAA WRGRKVRKTI KEIDKAATVI QSQYRMIRQR HCYRELREAA
KVVQLRYRAS KERDRHAHKY IAMRNAALCI QSAFRGMKVR RDLKAKHMAG AIIQRQYKCF
LERRRFVQLR NAVILTQQSF RMKVHAEQIR QEYLKLKTAV VVLQAAFRGW KVREKMNRMH
YSATIIQAAF RMHKAKDSYR TLKHAAIVLQ QKYKANTIGK SERKQYLKQR QAAITIQANF
RGMKDRKKMT CTIVHKAASK IQATFRMHQC KSQYIKIKWA VHVVQQRFRA NNLRDFAILQ
YHLIKKAVLC IQSCYRGFKV RKELEFQHRM ATRIQSAYKM YRRRVLYKNM QLSASRIQTW
YRSVATSRQA RAEFLQLRKA TILIQAACRG MLVRKNMKAM HTAATCIQSF YRMYRQRKYF
TIYLQAVCTI QQRYRAKMAR DHYFHSYQKT RKAATVIQAG FRGMKSRMLN QQKHQAAATM
QRAFKSFMER KSYLELSQYR ALVSGKAERQ KFLAYHNAVV CIQAAYRGFK EREKLKLRHR
AATQIQSLFR MHKLHISYLA NKQAAVVIQR YYRRYRSAKL ERMQYLKVCK AAIMVQALYR
GKRGRKTLRD MHKAATVVQA CYRMHRQKKY YLALQQAVRT TQIRFKANRA KADAVKQYAT
VRIAVKTIQP AFLARKAAEE TEMDSAVMIQ AEWKMHTFRR EFVKMKEAAV VIQAAFRGYR
TRKILKVMNV SACLIQQWYR TCCLTRLQRA HYLSIRSSAI TIQSAFRGML ARKVAKKEQA
ARKVQSFLVM TPHRRRFLRL RAAAIVLQSN YRMQRIRHAY EIQRESALVL HCCSKAPFTM
KSQKEADLEN ETRIDLETDG RQFSSMENAA IKIQAQWRGY IQRRMFLRYK SAALLLQQRY
RAHCFQKALH LQILQEQKAA TVIQAAYRAF KIRNNFVRLK QAALTIQKHF RALRTGRCER
IRYMQTRNAV LNLQACARGW LVRKEISVQN RRRHLMRIAY TLHLHLCAIK IQRRFKAHLA
LKHAGKHIRK VIFIQRWYRA KLQSRNRKAD LLYHQKVVTL QHAIRAWLQR RNNAACRIQR
GVREFLQRRH QARVVSGIVK FQALWRGYSC RKAQDTKAVQ VLRNRLQRVS QDVKEENKLC
NRTVVALDYL LSFKQLSFII AALQHLEVAT RLSAVCCENM AQSGAVKTIF VLIRSCNRSI
PCMEAIKLSV MVLLNLSKYE RTVQAVYEVE NSVDILLDLM QIFREKAGDK VSDKGGSIFT
KTCCLMAIFA LNSQRAKEIR TIPKAMERIR SIYKLTCRKH KMDAERSICR QRMSTDSNMS
IQATPVRTRV VSRIKPDWVL RKDNMREIVD PLKAIRMVME TLGVPS
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