ID A0A1L8GNS5_XENLA Unreviewed; 753 AA.
AC A0A1L8GNS5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RUN and TBC1 domain-containing protein 3 {ECO:0000256|ARBA:ARBA00030864};
GN Name=sgsm3.L {ECO:0000313|RefSeq:XP_018114344.1,
GN ECO:0000313|RefSeq:XP_018114345.1, ECO:0000313|RefSeq:XP_041446660.1,
GN ECO:0000313|Xenbase:XB-GENE-17331260};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018114345.1};
RN [1] {ECO:0000313|RefSeq:XP_018114344.1, ECO:0000313|RefSeq:XP_018114345.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018114344.1,
RC ECO:0000313|RefSeq:XP_018114345.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018114344.1,
RC ECO:0000313|RefSeq:XP_018114345.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC {ECO:0000256|ARBA:ARBA00006296}.
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DR RefSeq; XP_018114344.1; XM_018258855.2.
DR RefSeq; XP_018114345.1; XM_018258856.2.
DR RefSeq; XP_041446660.1; XM_041590726.1.
DR STRING; 8355.A0A1L8GNS5; -.
DR PaxDb; 8355-A0A1L8GNS5; -.
DR GeneID; 108714535; -.
DR KEGG; xla:108714535; -.
DR AGR; Xenbase:XB-GENE-17331260; -.
DR CTD; 108714535; -.
DR Xenbase; XB-GENE-17331260; sgsm3.L.
DR OMA; QKWYQPW; -.
DR OrthoDB; 12479at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 108714535; Expressed in pancreas and 19 other cell types or tissues.
DR CDD; cd17688; RUN_SGSM3; 1.
DR CDD; cd11813; SH3_SGSM3; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR035833; SGSM3_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF19; RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF02759; RUN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 115..306
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 482..541
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 557..720
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
SQ SEQUENCE 753 AA; 86315 MW; A07BB740A67F0803 CRC64;
MSGSYTPSPG GPFSALTASM WPQDMLAKYT QKEQTVEQPE FRYDEFGFRV DKEDGAEPNS
SKLLGIPLTE DPQQRLRWQA HLEFTHNHDV GDLTWDKIDV TLPHSDKLRS LVLAGIPHSM
RPQLWMRLSG ALQKKHNSEM TYKDIVRNSS NDDTLAAKQI EKDLLRTMPS NACFSNLQSV
GVPRLRRVLR GLAWLYPDIG YCQGTGMVAA CLLLFLEEED AFWMMAAIVE DLVPVSYFNT
TLVGVQTDQR VLRHLIVQYL PRLDKLLQEH DIELSLITLH WFLTAFANVV HIKLLLRIWD
FFFYQGSLVL FQTTLGMLKM KEEELIQSEN SASIFNTLSD IPSQIEEADV LLREAMLISG
TLTEVMIEAQ RRKHLAYLIA DQGQLLNSTA AVTNLSKIMR RQSQRRKSGI TTLLFGDDDF
EALKSKNIKQ TALVADLREA ILQVARHFQC TDPKNCSIDL TPDYTMESHQ RDHENYVSCS
RSRRRRAKAL LDFERHDDDE LGFRKNDIIT IISQKDEHCW VGELNGLRGW FPAKFVEILD
ERSKEYSVAG DDSVTEGITD VVRGTLCPSI KSIFEHGLKK PSLLGGPCHP WLFIEEAASR
EVERDFDSVY SRLVLCKTYR LDEDGKVLTP EELLYRGVQS VNVSHDAAHA QMDVKLRSLI
CIGLNEQVLH MWLEVLCSSL PTVEKWYQPW SFLRSPGWVQ IKCELRVLSK FAFSLSPDWE
LPVKREDKEK KPLKEGVQDM LVKHHLFSWD IDG
//
