ID A0A1L8GQE1_XENLA Unreviewed; 118 AA.
AC A0A1L8GQE1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Islet amyloid polypeptide {ECO:0000313|RefSeq:XP_018109975.1};
GN Name=iappl.S {ECO:0000313|RefSeq:XP_018109975.1,
GN ECO:0000313|RefSeq:XP_041443732.1,
GN ECO:0000313|Xenbase:XB-GENE-22064139};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041443732.1};
RN [1] {ECO:0000313|RefSeq:XP_018109975.1, ECO:0000313|RefSeq:XP_041443732.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018109975.1,
RC ECO:0000313|RefSeq:XP_041443732.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018109975.1,
RC ECO:0000313|RefSeq:XP_041443732.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the calcitonin family.
CC {ECO:0000256|ARBA:ARBA00009222}.
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DR RefSeq; XP_018109975.1; XM_018254486.2.
DR RefSeq; XP_041443732.1; XM_041587798.1.
DR STRING; 8355.A0A1L8GQE1; -.
DR PaxDb; 8355-A0A1L8GQE1; -.
DR GeneID; 108712242; -.
DR KEGG; xla:108712242; -.
DR AGR; Xenbase:XB-GENE-22064139; -.
DR CTD; 108712242; -.
DR Xenbase; XB-GENE-22064139; iappl.S.
DR OMA; CREAAPI; -.
DR OrthoDB; 3910643at2759; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR Bgee; 108712242; Expressed in brain.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR Gene3D; 6.10.250.2190; -; 1.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR018360; Calcitonin_CS.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR InterPro; IPR000443; IAPP.
DR PANTHER; PTHR10505; CALCITONIN-RELATED; 1.
DR PANTHER; PTHR10505:SF4; ISLET AMYLOID POLYPEPTIDE; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00818; ISLETAMYLOID.
DR SMART; SM00113; CALCITONIN; 1.
DR PROSITE; PS00258; CALCITONIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR621116-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..118
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041053353"
FT DOMAIN 71..113
FT /note="Calcitonin peptide-like"
FT /evidence="ECO:0000259|SMART:SM00113"
FT DISULFID 74..79
FT /evidence="ECO:0000256|PIRSR:PIRSR621116-50"
SQ SEQUENCE 118 AA; 13162 MW; 79092E25FB903B03 CRC64;
MSPLNLPLLL IVLSVSVSCG ETAPMDRLKS YDAPDWTKGW ISLQTRHTLF RPVNEIPQLD
NSRHKGHQLQ KRKCNTATCV TQRLADFLVR SNNNIGTIYS PTNVGSYTYG KRDLSGGS
//
