ID   A0A1L8GQE8_XENLA        Unreviewed;       982 AA.
AC   A0A1L8GQE8;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Lysine-specific demethylase 7A isoform X2 {ECO:0000313|RefSeq:XP_041443811.1};
GN   Name=kdm7a.S {ECO:0000313|RefSeq:XP_041443811.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041443811.1};
RN   [1] {ECO:0000313|RefSeq:XP_041443811.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041443811.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041443811.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954};
CC   -!- SIMILARITY: Belongs to the JHDM1 histone demethylase family. JHDM1D
CC       subfamily. {ECO:0000256|ARBA:ARBA00006942}.
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DR   RefSeq; XP_041443811.1; XM_041587877.1.
DR   AlphaFoldDB; A0A1L8GQE8; -.
DR   STRING; 8355.A0A1L8GQE8; -.
DR   PaxDb; 8355-A0A1L8GQE8; -.
DR   OMA; IRDERCH; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   CDD; cd15640; PHD_KDM7; 1.
DR   Gene3D; 1.20.58.1360; -; 1.
DR   Gene3D; 2.60.120.650; Cupin; 1.
DR   InterPro; IPR041070; JHD.
DR   InterPro; IPR003347; JmjC_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   PANTHER; PTHR23123:SF15; LYSINE-SPECIFIC DEMETHYLASE 7A; 1.
DR   PANTHER; PTHR23123; PHD/F-BOX CONTAINING PROTEIN; 1.
DR   Pfam; PF17811; JHD; 1.
DR   Pfam; PF02373; JmjC; 1.
DR   Pfam; PF00628; PHD; 1.
DR   SMART; SM00558; JmjC; 1.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS51184; JMJC; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ   SEQUENCE   982 AA;  111567 MW;  3C6E4D51D343F07F CRC64;
     MFEDSGIYGS SSALSASIGE TPPPGLGLQP MRRQELRQSV WRLLCVGACV LSPSPALSLV
     CDVWAGEWDL KMAGAAPVYC VCRQPYDVSR FMIECDICKD WFHGSCVKVE EHQAADIDLY
     HCPNCEVLHG PSQLKKRRNW HRHDYTESDD GARPVQAGTR TFIQALRARS FPCADDLLLR
     MNGSQLTQRY LEKQGFNLPI MVPRLDDLGL RLPPPTFSVM DVERYVGGEK IVDVIDVARQ
     ADSKMKLKNF VKYFMNPARP KVLNVISLEF SDTKMADLVK VPDISKKLSW VENYWPDDSL
     FTKPFVQKYC LMGVKDSYTD FHIDFGGTSV WYHVLWGEKI FYLIKPSDEN LALYESWSSS
     IAQSEEFFGD KVDKCYKCVV KQGHTLFVPT GWIHAVLTSQ DCMAFGGNFL HNLNIGMQLR
     CYEMEKRLKT PDLFKFPFFE AICWFVAKNL LETLKELRED GFHPPNYLKH GVKALISALK
     GWMKKESVAE HAFEIPDNVR PGHLVKELSK VIRSVEEEGN RPVKSQGIHG LCPLSQPSHE
     KSPHHSGRKA RRLRDHSTKP PSNLDILEQH TREVLKRLEM SPWEEDVGTY KLNISFNKPL
     QPSSTVPDQK AKDSGVRLVL SNGRIIRDEK QTFTDRSLYT ADSEDEDDRG RWRKAKEMGQ
     EKPCSTSGTE DKSETQKPLN MFFESVKSEL RNGSSEYSDI SDSDGSDDSC TNQKHFSEES
     ESSGDEEEER PEPIRVFKEE HSGRRLPCDP NFQWPDPDSP QKSECPTSTS MEQEAVQGML
     SMSALHYPPA LPTLPPSSDC KTTGSYPQLH INVSQGNREE HLDSHSPNTG HHVRDEGDLC
     RLDWMRQQES PCRTSRQDSY QLPKPSRGGS YEDYETSQKD QGYLELERWE SRQYQPDKYD
     PESSASSSEC HLSDGSLSPT RIYGDPSMAL PLHPTKRPAS NPPPISNQAT KGKRPKKGMA
     TAKQRLGKIL KLNRTGHTRF FV
//