ID A0A1L8GTN0_XENLA Unreviewed; 907 AA.
AC A0A1L8GTN0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Scm-like with four MBT domains protein 2 isoform X1 {ECO:0000313|RefSeq:XP_018111200.1, ECO:0000313|RefSeq:XP_018111201.1};
GN Name=sfmbt2.S {ECO:0000313|RefSeq:XP_018111200.1,
GN ECO:0000313|RefSeq:XP_018111201.1, ECO:0000313|RefSeq:XP_041444391.1,
GN ECO:0000313|Xenbase:XB-GENE-6488988};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018111200.1};
RN [1] {ECO:0000313|RefSeq:XP_018111200.1, ECO:0000313|RefSeq:XP_018111201.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018111200.1,
RC ECO:0000313|RefSeq:XP_018111201.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018111200.1,
RC ECO:0000313|RefSeq:XP_018111201.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_018111200.1; XM_018255711.2.
DR RefSeq; XP_018111201.1; XM_018255712.2.
DR RefSeq; XP_041444391.1; XM_041588457.1.
DR STRING; 8355.A0A1L8GTN0; -.
DR PaxDb; 8355-A0A1L8GTN0; -.
DR GeneID; 108713043; -.
DR KEGG; xla:108713043; -.
DR AGR; Xenbase:XB-GENE-6488988; -.
DR CTD; 108713043; -.
DR Xenbase; XB-GENE-6488988; sfmbt2.S.
DR OMA; RIELCCK; -.
DR OrthoDB; 5405166at2759; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR Bgee; 108713043; Expressed in zone of skin and 9 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR CDD; cd20114; MBT_SFMBT2_rpt2; 1.
DR CDD; cd09581; SAM_Scm-like-4MBT1_2; 1.
DR Gene3D; 2.30.30.140; -; 4.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037604; Scm-like-4MBT1/2_SAM.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF62; SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 2; 1.
DR Pfam; PF02820; MBT; 4.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 4.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 4.
DR PROSITE; PS51079; MBT; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 46..146
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 175..279
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 289..395
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 403..500
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 818..901
FT /note="PNT"
FT /evidence="ECO:0000259|SMART:SM00251"
FT DOMAIN 834..900
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
FT REGION 699..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..725
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..758
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 102971 MW; A7A907D546EE0596 CRC64;
MENRMLIIRC NQDTPHTSLE KSNSPTHGIK DMYCSDDGSS IEDTDFNWDE YLEESASSAA
PHTSFKHVEI SLQSSFQPGM KLEVANKSNP DTYWVATIIT TCGQLLLLRY CGYGEDRKAD
FWCDVMTADL HPIGWCTQNN KLLRPPDAAL GAIVFQRQQH FHVSNSTNAI KEECTDWAEF
LIHDLTGSRT APAKLLEGPL RGKTPVDLII ADSLIELQDK QNPFQYWIVR VIENIGGRLR
LRYAGLEESD SWDQWLFYLD YRLRPVGWCQ ENQFRMDPPI ELCPLRSISE WKSALEKSLV
EAARCPLPVE VFKDHADLRS HSLTYGMKVE VVEPEECNCI RPATVTKVFN NLYFQVTVDD
LRPEAKEVFM LCHADSLTLL PVQWCLINGV NLTSPKGYPG QDFDWADYQK QCGAEAVPDT
LFRNTSSSRS FTKDMKLEAV NPSNPAEICV ASVTKVKGRL MWLHLEGLQN PVPEYIVDVE
SMDIFPVGWC EANSYPLSTP LKAVVKKKKK VAVVQPEKQL PSSVPFETIP QELSPFPDNN
LTGNVNGKYC CPQLFINHRC FSGPFLNKGR IAELPQSVGP GKCVLVLKEV LSMVINAAYK
PGRVLRELQL VEDSLWNFQE ETLKAKYKGK TYRATVKIVR TSDQVADFCR KICSKLECCP
NLFSPLLITD VCPENCSVHT KTKYTYYYGK RKKITKPSVG EHSLENVQAK PTRRRKRRKS
IFVQKKRRTS TIDISPVESA EESIEDELMD DETGSEETSS ELRDDQTDTS SADVPSVRPQ
RAVTLRNRIV SERAPPVERA RRDRKTRSLP SIDGDTTLKT EMKEEEHLVL ESNPLQWTVT
DVVRFIRSTD CAPLAKIFQE QDIDGQALLL LTLPTVQECM ELKLGPAIKL CHQIERVKIA
FYAQYAN
//
