ID A0A1L8GTP3_XENLA Unreviewed; 584 AA.
AC A0A1L8GTP3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Uncharacterized protein LOC432286 isoform X1 {ECO:0000313|RefSeq:XP_018109720.1};
GN Name=net1.S {ECO:0000313|RefSeq:XP_018109720.1,
GN ECO:0000313|Xenbase:XB-GENE-17338719};
GN Synonyms=arhgef8 {ECO:0000313|RefSeq:XP_018109720.1}, net1a
GN {ECO:0000313|RefSeq:XP_018109720.1}, xNET1
GN {ECO:0000313|RefSeq:XP_018109720.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018109720.1};
RN [1] {ECO:0000313|RefSeq:XP_018109720.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018109720.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018109720.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_018109720.1; XM_018254231.2.
DR AlphaFoldDB; A0A1L8GTP3; -.
DR STRING; 8355.A0A1L8GTP3; -.
DR PaxDb; 8355-A0A1L8GTP3; -.
DR GeneID; 432286; -.
DR CTD; 432286; -.
DR Xenbase; XB-GENE-17338719; net1.S.
DR OrthoDB; 24012at2759; -.
DR Proteomes; UP000186698; Chromosome 3S.
DR Bgee; 432286; Expressed in lung and 19 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd13224; PH_Net1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR037853; Net1_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF4; NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ SEQUENCE 584 AA; 66596 MW; 8872809B3C351944 CRC64;
MEGEEIMATP AALTPPSENV KDKKRKGVKR KSSVTSLVEG PSTPERGNSR RYSLRRGSSF
TFLTPGSQWD FTLKRKRREK DDDALSVCSF DFKEPSTKRV RPLSRVTSLA NLISPVRNGA
VRRFGQTIQS FTMRAENKSP GSTQKACSKV AAPTPPKRRN SVLWSEMLGI NMKESLSTKE
IKRQEAIFEM TKGEQDLIED LKLARKAYHD PMLKLSIMSE EELTQIFGDL DSYIPLHEEL
LAKLGVATKA DGRVGQIGPI LINWLPRLNA YKEYCSNQLA AKALLDKKKL DRRVQDFLQR
CLESPFSRKL DLWSFLDIPR SRLVKYPLLL KEILRHTPKD HPDTTALEEA LCLIQGVLTD
INLKKGESEC QYYIDKLEYL DDKQKDLRIE SSKALLCHGE LKNKNGHKLF LFLFQDVLVL
TRPVIRNEHQ YFQVYRQPIP VQELVLEDLQ DGDVRMGGSF RGAFSNSDKA KNIFRVRFKE
SCAGQSHTLQ ANDVFHKQQW LNCIKTAISP YQQASPTEQK ELPDLSEECE ENHPPATNGK
APKRLSISGI MEMDLEENAF SPLLDVTEDT KIRDKTPQKK ETLV
//