ID   A0A1L8GW72_XENLA        Unreviewed;      1285 AA.
AC   A0A1L8GW72;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=DENN domain-containing protein 5B isoform X3 {ECO:0000313|RefSeq:XP_018107378.1};
GN   Name=dennd5b.L {ECO:0000313|Xenbase:XB-GENE-6488746};
GN   Synonyms=LOC108710730 {ECO:0000313|RefSeq:XP_018107378.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018107378.1};
RN   [1] {ECO:0000313|RefSeq:XP_018107378.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018107378.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018107378.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC       {ECO:0000256|ARBA:ARBA00006664}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR   RefSeq; XP_018107378.1; XM_018251889.2.
DR   STRING; 8355.A0A1L8GW72; -.
DR   PaxDb; 8355-A0A1L8GW72; -.
DR   GeneID; 108710730; -.
DR   CTD; 108710730; -.
DR   Xenbase; XB-GENE-6488746; dennd5b.L.
DR   OMA; LYQMHHA; -.
DR   OrthoDB; 5398783at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 108710730; Expressed in camera-type eye and 19 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   CDD; cd01757; PLAT_RAB6IP1; 1.
DR   CDD; cd17693; RUN2_DENND5B; 1.
DR   Gene3D; 1.20.58.900; -; 2.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR047278; DEN5A/B.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR047277; PLAT_RAB6IP1.
DR   InterPro; IPR047292; RUN2_DENND5B.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR46070:SF3; DENN DOMAIN-CONTAINING PROTEIN 5B; 1.
DR   PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   Pfam; PF02759; RUN; 2.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00593; RUN; 2.
DR   SMART; SM00800; uDENN; 1.
DR   SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR   SUPFAM; SSF140741; RUN domain-like; 2.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS50095; PLAT; 1.
DR   PROSITE; PS50826; RUN; 2.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ   SEQUENCE   1285 AA;  146015 MW;  6DFA11AE31F75046 CRC64;
     MSGSSGTAGP PCRLAHYFVI CGTDADSGLE PDELAVLYQW LEADRHGRGH DTGENFEQSP
     LRRTFKSKVL AHYPQNVEWN PFDQDAVNML CMPKGLSFRT QADNRDPEFH SFIITREDGS
     RTYGFVLTFF EEVTSKQMCA AMQTLYHMHN AEQSGSVYAS SSCSMDSLAS SMEDGDDTSL
     AKTQQRYNSY DISKDTLYVS KCICLITPLP FMRSCKKFLT QLYKAVNSPQ PPPLPLESYI
     HNLLYEVPLP PPGRSLKFYG VYDPIVCQRP GPSELPLSDY PLRETFELLG LENLVQLFTC
     VLLEMQILLY SQDYQRLMTV AEGITSLLFP FQWQHVYVPI LPASLLHFLD APVPYLMGLQ
     SKEGTDRSKL ELPQEANLCF VDIDNHFIEL PEEFPQFPNK LEFIQEISEV LLQYGIPPEG
     NLHCSESATK LKSLVLDDWV NDKKNGNLSA NNINMYELLK GNETIARLQA LTKRTGITMD
     KINLAAPTMD PEEEQKVQCA EKELQDYKLN VQLREVFASR FTQMFSDYEA FVIQSAHDME
     SWLNNREQMQ NFDKASFLSD QPEPYLPFLS RFIETQMFAT FIDNKIMSLW DEKEPLLRVF
     DSRIQKTRLY NGRAPALRTS NYQKCTTLKE AAQAIEQRLT KIDHTAVHPH LLDMKIGQGK
     YEQGFFPKLQ SDVLMTGPTN NNRWVSRSAT AQRRKDKLRQ HSEHLGLDND LREKYMQEAR
     GLGKTVRQPK LSDLSPAVIA QTNSKFVEGL LKECRMKTKR MLVEKMGHEA VELGHGEANI
     TGLEENTLIA SLCDLLERIW SHGLLIKQGK SALWSHLVQF QEREERLEHM AESPMAPGPD
     RRKSDTGVSL PSLRVSLIQD MRHIQNLSEI KTDVGRARGW IRLSLEKKLL SQHLKQLLTN
     QSLTKKLYKR YAFLRCEEEK EQFLYHLLSL NAVDYFCFTS VFTTIVVPYR VLIIPIKKLS
     NAINTSNPWI CVSGEFGDTG VMQIPKNLLE MTFESQNLGK MTTVQLGHDN SGLLAKWLVD
     CVMVRNEITG HTYKFPCGRW LGKGVDDGSL ERVLIGELIT PMSDDDLGKQ SRTPPQQKSP
     TVARRLSITS LTGKNNKPNA GQIQEGIGEA VNNIVKHFHK PEKERGSLTV LLCGESGLVA
     ALEQFFHHGF KSARIFQKSV FIWDFIEKAV VYFETTDQIG DGEADQLIPR SSCKTFCHYV
     NTIVAAPRNI GKDGKFQLLV CLGARDHLLA LWIPLLAECP AITRMYEENA LLRDPMTVNT
     LIRVLQTLQD FNIVLEGSLV KGVDV
//