ID A0A1L8GWJ1_XENLA Unreviewed; 318 AA.
AC A0A1L8GWJ1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Melatonin receptor type 1A X2.0 {ECO:0000313|RefSeq:XP_018107436.1};
GN Name=mtnr1al.L {ECO:0000313|Xenbase:XB-GENE-5911705};
GN Synonyms=mel.L {ECO:0000313|RefSeq:XP_018107436.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018107436.1};
RN [1] {ECO:0000313|RefSeq:XP_018107436.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018107436.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018107436.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_018107436.1; XM_018251947.2.
DR AlphaFoldDB; A0A1L8GWJ1; -.
DR STRING; 8355.A0A1L8GWJ1; -.
DR PaxDb; 8355-A0A1L8GWJ1; -.
DR GeneID; 108710792; -.
DR KEGG; xla:108710792; -.
DR AGR; Xenbase:XB-GENE-5911705; -.
DR CTD; 108710792; -.
DR Xenbase; XB-GENE-5911705; mtnr1al.L.
DR OMA; YLRIWIF; -.
DR OrthoDB; 5397093at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 108710792; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000025; Melatonin_rcpt.
DR PANTHER; PTHR24228; B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR; 1.
DR PANTHER; PTHR24228:SF49; MELATONIN RECEPTOR TYPE 1A-LIKE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00857; MELATONINR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000313|RefSeq:XP_018107436.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 44..296
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 318 AA; 36292 MW; 51A4CCDD9FD499F0 CRC64;
MEEERTTQRN ISGELKDEDD DYPTWAVSTL TTILVVTISG DIVGNLLVIT SVFRNKKLRK
AGNAFVVSLA VADLLVACYP YPLVLLAIFN HGWRMGHLHC QMSGFFMGLS VISSVFNITG
IAVNRYCYIC HSSWYNRLFS NSSTICYVGL VWVLALAAIL PNLFVGSLRY DPRIFSCTFA
QSVSSYYTIA VVIFHFFLPI GVVSYCYLRI WVLVLNIRHR VKPDRHLHHQ TWPYNIHGFI
TMFVVFVLFA VCWGPLNIIG LTVAIYPPLG DSIPQWLFVA SYFMAYFNSC LNAVVYGALN
RNFRREYKKI LLNIFQLT
//
