ID A0A1L8GXT9_XENLA Unreviewed; 393 AA.
AC A0A1L8GXT9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Alpha-2Db adrenergic receptor {ECO:0000313|RefSeq:XP_018107693.1};
GN Name=LOC108710968 {ECO:0000313|RefSeq:XP_018107693.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018107693.1};
RN [1] {ECO:0000313|RefSeq:XP_018107693.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018107693.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018107693.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_018107693.1; XM_018252204.2.
DR AlphaFoldDB; A0A1L8GXT9; -.
DR STRING; 8355.A0A1L8GXT9; -.
DR PaxDb; 8355-A0A1L8GXT9; -.
DR GeneID; 108710968; -.
DR KEGG; xla:108710968; -.
DR OMA; CHISKPL; -.
DR OrthoDB; 3087922at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 108710968; Expressed in spleen and 16 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004935; F:adrenergic receptor activity; IEA:InterPro.
DR CDD; cd15324; 7tmA_alpha-2D_AR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR002233; ADR_fam.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF0; ADRENOCEPTOR ALPHA 2B-LIKE 2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01103; ADRENERGICR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000313|RefSeq:XP_018107693.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 50..370
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 393 AA; 44990 MW; 31103412C26B8F25 CRC64;
MEATSFVPTA FYNGSEESGQ PQLKAWPYTA LECTLIIIAV VSIILSTVLG NILVVLAIFT
SRALRAPQNL FLVSLASADI LVGALIIPFS LAREVMGYWH FGSVWCSMYL ALDILFCTSS
IVHLCAISID RYWSVTKAVK YNLKRTPKRI KRCIAIIWVV SAIISFPPLL KSKHKEWECL
LNDDTWYVLF SCTVSFFVPC LIMILLYCRI YRVAKHRVSS LRNGVSDCAS ATPGTCETHH
NIQNNHEAEE LDLEESTSSV HKFPKKHHHK KKDKPKSAKA KRLSWTSNRG QQHRDQSICI
SQMRLNQLRE KRLTFVLAVV IGGFVICWFP FFFTYSLESV CRKRCGISDA LFNFFFWIGY
CNSSLNPIIY TVFNRDFRKA FRRLLTHGSR RTT
//
