ID A0A1L8GZG6_XENLA Unreviewed; 510 AA.
AC A0A1L8GZG6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X3 {ECO:0000313|RefSeq:XP_018108242.1};
GN Name=pfkfb3.L {ECO:0000313|RefSeq:XP_018108242.1,
GN ECO:0000313|Xenbase:XB-GENE-17340406};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018108242.1};
RN [1] {ECO:0000313|RefSeq:XP_018108242.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018108242.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018108242.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: In the C-terminal section; belongs to the phosphoglycerate
CC mutase family. {ECO:0000256|ARBA:ARBA00008408}.
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DR RefSeq; XP_018108242.1; XM_018252753.2.
DR AlphaFoldDB; A0A1L8GZG6; -.
DR STRING; 8355.A0A1L8GZG6; -.
DR PaxDb; 8355-A0A1L8GZG6; -.
DR GeneID; 108711232; -.
DR KEGG; xla:108711232; -.
DR AGR; Xenbase:XB-GENE-17340406; -.
DR CTD; 108711232; -.
DR Xenbase; XB-GENE-17340406; pfkfb3.L.
DR OMA; PRCIYLT; -.
DR OrthoDB; 2013830at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 108711232; Expressed in egg cell and 19 other cell types or tissues.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR PANTHER; PTHR10606:SF41; 6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 3; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 29..247
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT BINDING 254..261
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 304
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 510 AA; 58129 MW; C49ABF91E83838D1 CRC64;
MPMELTQNRI QKIWLPRDEL PQLPINVGGP QFANSPTVIV MVGLPARGKT YISKKLTRYL
NWSGVPTKVF NVGEYRREAV KDFSSHDFFR ADNTEAMKIR RHCALAALAD VKSYLTKEGG
QIAVFDATNT TRERRSMVVD FAKENEFKVF FIESVCDDPS VVASNVLEVK LSSPDYKGCT
SNVALEDFMK RINCYKNSYE PLDPDHHDRD LSMIIVIDVG RRFLVNRVQD HIQSKIVYYL
MNIHVQPRCI YLCRAGESES NLNGKIGGDS GLSHRGKKFA ITLKKYIEDQ NLKELKVWTS
QLKRSIQTAE ALKLPYEQWK ALNELDAGVC EEKTYEEIKE LYPEEYALRA QDKYHYRYPS
GESYQDLVQR LEPVIMELER QGNVLVICHQ AVLRCLLSYF LDKPADEMPY LKCPLHSMLK
LTPFAYGCHV ETVPFSVDAV NTHRDRIIED CKKCPTPLMR RNSVTPLASP EPTKKARINS
FEEFAACSSV GCASQEPQSG QPLLGKACLA
//
