ID A0A1L8GZQ3_XENLA Unreviewed; 169 AA.
AC A0A1L8GZQ3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Leptin {ECO:0000256|ARBA:ARBA00021421, ECO:0000256|PIRNR:PIRNR001837};
DE AltName: Full=Obesity factor {ECO:0000256|ARBA:ARBA00030981, ECO:0000256|PIRNR:PIRNR001837};
GN Name=lep.L {ECO:0000313|RefSeq:XP_018108304.1,
GN ECO:0000313|Xenbase:XB-GENE-17342421};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018108304.1};
RN [1] {ECO:0000313|RefSeq:XP_018108304.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018108304.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018108304.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Key player in the regulation of energy balance and body
CC weight control. Once released into the circulation, has central and
CC peripheral effects by binding LEPR, found in many tissues, which
CC results in the activation of several major signaling pathways.
CC {ECO:0000256|PIRNR:PIRNR001837}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR001837}.
CC -!- SIMILARITY: Belongs to the leptin family.
CC {ECO:0000256|ARBA:ARBA00005834, ECO:0000256|PIRNR:PIRNR001837}.
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DR RefSeq; XP_018108304.1; XM_018252815.2.
DR AlphaFoldDB; A0A1L8GZQ3; -.
DR SMR; A0A1L8GZQ3; -.
DR STRING; 8355.A0A1L8GZQ3; -.
DR PaxDb; 8355-A0A1L8GZQ3; -.
DR GeneID; 108711253; -.
DR KEGG; xla:108711253; -.
DR AGR; Xenbase:XB-GENE-17342421; -.
DR CTD; 108711253; -.
DR Xenbase; XB-GENE-17342421; lep.L.
DR OMA; TIMGCTT; -.
DR OrthoDB; 5346301at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 108711253; Expressed in muscle tissue and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000065; Leptin.
DR PANTHER; PTHR11724; LEPTIN; 1.
DR PANTHER; PTHR11724:SF1; LEPTIN; 1.
DR Pfam; PF02024; Leptin; 1.
DR PIRSF; PIRSF001837; Leptin; 1.
DR PRINTS; PR00495; LEPTIN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Secreted {ECO:0000256|PIRNR:PIRNR001837}.
SQ SEQUENCE 169 AA; 19624 MW; 974CE93DBCD6D9CC CRC64;
MQYTQLSFWG IFWMLLPMIQ GRAIKTDRVK NDAKMLARTL ITRIQEHPIQ YLFPSNLKIS
GLDFIPDEQL LESLEHMDET LEVFQEILSS LPMENVDQML SDMENLRSLL QLLSTIMGCT
TRKHSQSDTQ VNLTEEYAKA PYTTEKVALD RLQKSLHSIV KHLDHITNC
//
