ID A0A1L8GZX7_XENLA Unreviewed; 529 AA.
AC A0A1L8GZX7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN Name=arih1.L {ECO:0000313|RefSeq:XP_041441207.1,
GN ECO:0000313|Xenbase:XB-GENE-972163};
GN Synonyms=ARI-1 {ECO:0000313|RefSeq:XP_041441207.1}, ariadne
GN {ECO:0000313|RefSeq:XP_041441207.1}, arih1
GN {ECO:0000313|RefSeq:XP_041441207.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041441207.1};
RN [1] {ECO:0000313|RefSeq:XP_041441207.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041441207.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041441207.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
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DR RefSeq; NP_001089823.1; NM_001096354.1.
DR RefSeq; XP_018106743.1; XM_018251254.1.
DR RefSeq; XP_018106744.1; XM_018251255.1.
DR RefSeq; XP_018106745.1; XM_018251256.1.
DR RefSeq; XP_018106746.1; XM_018251257.1.
DR RefSeq; XP_018106747.1; XM_018251258.1.
DR RefSeq; XP_041441207.1; XM_041585273.1.
DR AlphaFoldDB; A0A1L8GZX7; -.
DR SMR; A0A1L8GZX7; -.
DR STRING; 8355.A0A1L8GZX7; -.
DR PaxDb; 8355-A0A1L8GZX7; -.
DR GeneID; 734889; -.
DR KEGG; xla:734889; -.
DR AGR; Xenbase:XB-GENE-972163; -.
DR CTD; 734889; -.
DR Xenbase; XB-GENE-972163; arih1.L.
DR OMA; HQMDDIE; -.
DR OrthoDB; 3084186at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 734889; Expressed in testis and 19 other cell types or tissues.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20343; BRcat_RBR_HHARI-like; 1.
DR CDD; cd20356; Rcat_RBR_HHARI-like; 1.
DR CDD; cd16626; RING-HC_RBR_HHARI; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR048962; ARIH1-like_UBL.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685:SF212; E3 UBIQUITIN-PROTEIN LIGASE ARIH1; 1.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF21235; ARI1_UBAl; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 529 AA; 61684 MW; A23153529BFFEFCB CRC64;
MDSDEGYNYE FDDEEECSEE SGADEHEDEL ELGEVELVEA GLSGSERAGL CGEGGGSALG
PGPGGEEDED YRYEVLTAEQ ILQHMVECIR EVNEVIQNPA TITRILLSHF NWDKEKLMER
YFDGNLEKLF SECHVINPSK KSRTRQMNTR SSALDMPCQI CYLNYPNSYF TGLECGHKFC
MQCWGEYLTT KIIEEGMGQT ISCPAHGCDI LVDDNTVMRL ITDSKVKLKY QHLITNSFVE
CNRLLKWCPA PDCHHVVKVQ YPDAKPVHCK CGRQFCFNCG ENWHDPVKCK WLRKWIKKCD
DDSETSNWIA ANTKECPKCH VTIEKDGGCN HMVCRNQNCK AEFCWVCLGP WEPHGSAWYN
CNRYNEDDAK AARDAQERSR AALQRYLFYC NRYMNHMQSL RFEHKLYAQV KQKMEEMQQH
NMSWIEVQFL KKAVDVLCQC RSTLMYTYVF AFYLKKNNQS IIFENNQADL ENATEVLSGY
LERDISQDSL QDIKQKVQDK YRYCESRRRV LLLHVHEGYE KDLWEYIED
//
