ID   A0A1L8H0K6_XENLA        Unreviewed;      1063 AA.
AC   A0A1L8H0K6;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Ubiquitin specific peptidase 8 L homeolog isoform X2 {ECO:0000313|RefSeq:XP_018106213.1};
GN   Name=usp8.L {ECO:0000313|RefSeq:XP_018106213.1,
GN   ECO:0000313|Xenbase:XB-GENE-969029};
GN   Synonyms=usp8 {ECO:0000313|RefSeq:XP_018106213.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018106213.1};
RN   [1] {ECO:0000313|RefSeq:XP_018106213.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018106213.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018106213.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_018106213.1; XM_018250724.1.
DR   AlphaFoldDB; A0A1L8H0K6; -.
DR   STRING; 8355.A0A1L8H0K6; -.
DR   PaxDb; 8355-A0A1L8H0K6; -.
DR   GeneID; 380243; -.
DR   AGR; Xenbase:XB-GENE-969029; -.
DR   CTD; 380243; -.
DR   Xenbase; XB-GENE-969029; usp8.L.
DR   OMA; WANREER; -.
DR   OrthoDB; 227085at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 380243; Expressed in pancreas and 19 other cell types or tissues.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0019538; P:protein metabolic process; IEA:UniProt.
DR   CDD; cd02674; Peptidase_C19R; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   InterPro; IPR015063; USP8_dimer.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR048498; WW_USP8.
DR   PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   PANTHER; PTHR21646:SF27; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8; 1.
DR   Pfam; PF00581; Rhodanese; 1.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF08969; USP8_dimer; 1.
DR   Pfam; PF20625; WW_USP8; 1.
DR   SMART; SM00450; RHOD; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR   SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ   SEQUENCE   1063 AA;  120589 MW;  8E5E1E1FA1944892 CRC64;
     MPTVSALPKE LYLSSSLSDL KKKAEVKPDK TSTKSYVSSA CKIFQKAEEC RLEGDEEKAY
     VLYMKYLFVF ELLKKRSDFK QNQDYYKSLL GPSTILKSVE EAEKLSESLK NRYEEAEVRK
     KLEERERQED LKKKQGKLFP KDFPEDVPSQ LNTNATVNGG GNEVLSKEPE PAKVPLGAIT
     AEKLFEMTND YNISIIIMDV RNTKDFEESH IRTSISVPQE AITPGFTSSK IELNLPDESI
     EMWNKRGHVD YIILLDWFSS VNDLKIGTTL QSLKDALCKW ETKIILRSEP LVLDGGYENW
     LLCYPMFTTN GKVTVPRKRK HESVSLSLDF NYPSLEEPTA PPSVAKEELP SVPIKVSSNE
     DVINAVKTQK TEEPVHVIQK DDPVPEVHTD SVNVCHPQIT AKVIPQIDRT KKPSVTVTES
     TTKFKPEAKE KQAMLNGKPI PDRSTKPSLD SKSVKAEIHV QFDKNIKEKS VESKGKVIVN
     AEDKADNTCA HEDKENTKRN DEKEYEMREL HKKEEIEKKH PFAAGKEPSE PKRLDSDKPS
     PDDRKKNVNS SVPPEGPPAN REEDKSDVTV KDSCEEDRPK REPLVRARSE EMGRSVPGMP
     EGWVKFLEPI TGTYRYYHSP THTVHMYPPE MASSSTHSTT PAQKAKIQAH TDTDREQTKL
     KRSYSSPDLA QAIKDEDKKK PTPHINRENK PSIVNTKAEI TKLPASKIRS LNPVFGGAGP
     ALTGLRNLGN TCYMNSILQC LCNTPHLAEY FNKNCYQADI NRSNLLGHKG EVAEEFGCIM
     KALWTGQYKC ISPKDFKITI GKINEQFAGY SHQDSQELLL FLMDGLHEDL NKADNRKRQK
     EENNDHLSDS QAADSAWYKH KQLNESIIVS LFQGQFKSTV QCLTCQKKSR TFEAFMYLSL
     PLPSTSKCSL KDCIKAFAKE EKLTDSNRFD CSNCKTQRVA TKKIEIWKLP PILLVHLKRF
     SFEGRWRQKL QAYVDFPLES LDLSPYVIGP KSSKKYNLFG VSNHYGGLDG GHYTAYCKNA
     LKQRWFKFDD HDVSDISVSS VKTSAAYMLF YTSLDLRGLE ISA
//