ID A0A1L8H168_XENLA Unreviewed; 362 AA.
AC A0A1L8H168;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=TIMELESS-interacting protein {ECO:0000256|ARBA:ARBA00018750, ECO:0000256|RuleBase:RU366049};
GN Name=tipin.L {ECO:0000313|RefSeq:XP_018106256.1,
GN ECO:0000313|Xenbase:XB-GENE-17340911};
GN Synonyms=tipin {ECO:0000313|RefSeq:XP_018106256.1}, xtipin
GN {ECO:0000313|RefSeq:XP_018106256.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018106256.1};
RN [1] {ECO:0000313|RefSeq:XP_018106256.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018106256.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018106256.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays an important role in the control of DNA replication and
CC the maintenance of replication fork stability.
CC {ECO:0000256|RuleBase:RU366049}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU366049}.
CC -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000256|ARBA:ARBA00006075,
CC ECO:0000256|RuleBase:RU366049}.
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DR RefSeq; XP_018106256.1; XM_018250767.2.
DR AlphaFoldDB; A0A1L8H168; -.
DR STRING; 8355.A0A1L8H168; -.
DR PaxDb; 8355-A0A1L8H168; -.
DR GeneID; 394376; -.
DR AGR; Xenbase:XB-GENE-17340911; -.
DR CTD; 394376; -.
DR Xenbase; XB-GENE-17340911; tipin.L.
DR OrthoDB; 2920045at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 394376; Expressed in egg cell and 19 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:UniProtKB-UniRule.
DR GO; GO:0031297; P:replication fork processing; IEA:UniProtKB-UniRule.
DR InterPro; IPR012923; Csm3.
DR InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR PANTHER; PTHR13220; TIMELESS INTERACTING-RELATED; 1.
DR PANTHER; PTHR13220:SF11; TIMELESS-INTERACTING PROTEIN; 1.
DR Pfam; PF07962; Swi3; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU366049};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU366049};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366049};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 73..153
FT /note="Chromosome segregation in meiosis protein 3"
FT /evidence="ECO:0000259|Pfam:PF07962"
SQ SEQUENCE 362 AA; 40476 MW; 626CECDF689045E7 CRC64;
MMDPLDNGLF DLPDYEHTED ENFPPLPPPH SPGADDEADD VANGDDWTEN AGQTQREEAP
KPARRVVKRP QPKLDGQRLA SQRGLPALRH MFDDVKFKGK GHETEDLKIL LRQMENWAHR
LFPKLQFEDF LNRLESMGNK KEVQTCLKKI RMDLPIVHDD FLSEEVVVQT EDHAIDMPSE
DFSFPDELHV PSQSQPVKVD LSEETLQRIE RNRRLALERR MEKMQAQAES QALSQATQSD
PNEIPDDAFD AEMLDAVESM TGILTASQSP PHVDKDLSLV LHSHDLPVQD VSQSPAPCPK
PQGDAPSEKA LGLVHSALPS TSDPTSPRKP LTEQLPDDSD ADTSSATPHT EAPACANTKE
EY
//
