ID A0A1L8H9S2_XENLA Unreviewed; 545 AA.
AC A0A1L8H9S2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Serine hydroxymethyltransferase {ECO:0000256|RuleBase:RU000585};
DE EC=2.1.2.1 {ECO:0000256|RuleBase:RU000585};
GN Name=shmt2.S {ECO:0000313|RefSeq:XP_018105549.1,
GN ECO:0000313|Xenbase:XB-GENE-17342715};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018105549.1};
RN [1] {ECO:0000313|RefSeq:XP_018105549.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018105549.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018105549.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Interconversion of serine and glycine.
CC {ECO:0000256|RuleBase:RU000585}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O =
CC (6S)-5,6,7,8-tetrahydrofolate + L-serine; Xref=Rhea:RHEA:15481,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15636, ChEBI:CHEBI:33384,
CC ChEBI:CHEBI:57305, ChEBI:CHEBI:57453; EC=2.1.2.1;
CC Evidence={ECO:0000256|RuleBase:RU000585};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU000585};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU000585}.
CC -!- SIMILARITY: Belongs to the SHMT family. {ECO:0000256|ARBA:ARBA00006376,
CC ECO:0000256|RuleBase:RU000585}.
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DR RefSeq; XP_018105549.1; XM_018250060.1.
DR AlphaFoldDB; A0A1L8H9S2; -.
DR STRING; 8355.A0A1L8H9S2; -.
DR PaxDb; 8355-A0A1L8H9S2; -.
DR GeneID; 108709854; -.
DR KEGG; xla:108709854; -.
DR AGR; Xenbase:XB-GENE-17342715; -.
DR CTD; 108709854; -.
DR Xenbase; XB-GENE-17342715; shmt2.S.
DR OMA; WFRGVQY; -.
DR OrthoDB; 5358603at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 108709854; Expressed in kidney and 20 other cell types or tissues.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00378; SHMT; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR HAMAP; MF_00051; SHMT; 1.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR InterPro; IPR039429; SHMT-like_dom.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF65; SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF00464; SHMT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00096; SHMT; 1.
PE 3: Inferred from homology;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563,
KW ECO:0000256|RuleBase:RU000585};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|RuleBase:RU000585};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000585}.
FT DOMAIN 91..489
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
SQ SEQUENCE 545 AA; 59926 MW; 69FCC226A96C7A96 CRC64;
MPALCKQFIV MPPCGSVAGV SAHDHTCALI HTGARGRSGV AVLSRGLIEM LTFSIRRLAQ
PLRRCCHVRS QHSQAWTQAG NQVWTGQESL AEGDPEMWNL VQKEKDRQCR GLEMIASENF
CSRAALEALG SCLNNKYSEG YPGKRYYGGA EVVDQIELLC QQRALHAFDL DPEKWGVNVQ
PYSGSPANFA AYTAVLQPHD RIMGLDLPDG GHLTHGYMSD VKRISATSIY FESMPYKLNP
GTGLIDYDQL ELTARLFRPK LIIAGTSAYA RLIDYARMRK VCDEVKAYLL ADMAHISGLV
AAGVIPSPFD HADIVTSTTH KTLRGARSGL IFFRKGVKSV DKKTGKEILY NLEDKVNFSV
FPSIQGGPHN HAIAAVAVAL KQASSPMFRE YAVQVLKNAK SMAAALLSKG YTLVSGGTDN
HLVLVDLRPK GIDGARAERV LELVSVTANK NTCPGDKSAL TPGGLRLGAP ALTSRNFKEA
DFEKVVDFID EGIRIGLDVK RKTNKLQDFK NFLLEDKETV NRIAELRKQV EQFARAFPMP
GFDER
//
