ID   A0A1L8HBQ4_XENLA        Unreviewed;      1500 AA.
AC   A0A1L8HBQ4;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 2 {ECO:0000313|RefSeq:XP_041440625.1};
GN   Name=LOC108710098 {ECO:0000313|RefSeq:XP_041440625.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041440625.1};
RN   [1] {ECO:0000313|RefSeq:XP_041440625.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041440625.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041440625.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. LTrpC
CC       subfamily. TRPM2 sub-subfamily. {ECO:0000256|ARBA:ARBA00009501}.
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DR   RefSeq; XP_018105992.1; XM_018250503.1.
DR   RefSeq; XP_041440625.1; XM_041584691.1.
DR   STRING; 8355.A0A1L8HBQ4; -.
DR   PaxDb; 8355-A0A1L8HBQ4; -.
DR   KEGG; xla:108710098; -.
DR   OMA; NRCASIR; -.
DR   OrthoDB; 201873at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 108710098; Expressed in brain and 4 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.450; -; 1.
DR   Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR041491; TRPM_SLOG.
DR   PANTHER; PTHR13800:SF2; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 2; 1.
DR   PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF18139; LSDAT_euk; 1.
DR   SUPFAM; SSF102405; MCP/YpsA-like; 1.
DR   SUPFAM; SSF55811; Nudix; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000313|RefSeq:XP_041440625.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022568}.
FT   DOMAIN          134..391
FT                   /note="TRPM SLOG"
FT                   /evidence="ECO:0000259|Pfam:PF18139"
FT   DOMAIN          812..1062
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
SQ   SEQUENCE   1500 AA;  169449 MW;  B506ECAF33179768 CRC64;
     MGNTKSKSPV PDRIDGVQLH SNVNSPHRPG TADPKKKKKT APKFIDGEKV DVLNSWVSQN
     IRKKECVTFI PQVSETPSDR DKCGCGHTRH THFEDHISSS VEPGTVWDPH KHVREFPSDA
     HGDLTFTGTT RTWAKYVRAS NDTPPRLLFN LLTQQWDLSV PNLLISVTGG AKNFNISPRL
     KTEFSRGLVT AAQSTGAWII TGGSHAGVMK HVGEAVRDFS GGQHESDIVL IGIATWGIVH
     NKEALISEAG GAPAVYHMDE GSQGSLCCLD NNHTHFILVD NGTCGKYGVE IPLRAKLEKY
     ISAQTMEKAG TTIKIPIVCV VLEGGPGTLD TIYNSMCNNT PCVIVEGSGR VADIIAQVAH
     LRISRITISL VKEKLQNLFQ DTYESFTEAQ ITMWTKKIQD IVRMGSLLTI LRDDKTEEQG
     MDVAILQALL KASRSTDNSG QENWDHQLKL AVAWNRPDIA ESQIFTEDWL WKTSDLYASL
     MVSLVDDKPS FLRLFLERGV SLSEFLTWDV LTELYNNTEP SSLIHSKLER QAMLDESTDM
     NGPKIQLHHV SRVLQELLGG LTEPLYPDGR SHRTRNLAHI NIKISGKVSS MRLASDCTLQ
     LEHPVRDLLI WCIVQNRAEL AEIIWCQSQD CIVGALACRK ILKALSKEED DTESMENMKK
     LADVYEERAA GVFSECYESD ESRAEQLLIR VSSIWGKTTC LDLAQESQGQ AFMSQGGVQM
     FLNKTWCGKL SVDNGLLAIL LCMLLFPLIY TGLVMYRKEP LAPRSSRRTD TNGQMKSPVR
     SSQTRNCLRT FLHFFTAPIV KFYYNVVSYV GFLWLFAYVL MMNFQTSPSW SEYILYGWVF
     AILCEELRQL LYDPDRLGFV VKSVQYISEF WNQIDSLALV LFAVGLICRL ASVDTVYLGR
     IFLSIDFMIF CVRLLHIFTV SKVLGPKIIM LRRMVMDLFF FFFLLAIWIL SFGVAKQAIL
     TSNEIRLNWI FRNVVYGPYL TLFGQMPSDI DGLNFDPTKC SQDGTNPLLP KCVYNDGSGN
     ALFPEWLTII LMCIYLLMAN ILLMNLLIAI FSNTFGDVES HTDQIWKFYR FGLIKEYNER
     PAAPPPFILL SHFYFLLKYG LSKRSTMSHK AMRCIMDEAG ESSLLSWELY MRDNYVHNQQ
     LLDAQSQENV VKNTADSVSA VLKLLNMEKG SDGQNMERRL YLLEDQVSRS SQQLQWIVSA
     LQEKGFTGTG QMLVHSKSQD LEEKASLGSD SLGDKKSVYH VNSRTLQYPN SNVTRYPVPD
     EMVPWEVTFP GYDPPFLIAD RDDRGPYDPH SEMSQTNRKY NGVDGALDLR SSCGTYLVQH
     GLPLNPMGRT GLRGVGSLRW FGPNHSLHPV ITRWNTRPNG SVDRKISRKM LEILVVKQIE
     NELWALPGGT LSPGEEIPSK LQSILNEKYV KQFSDLLRGG TEVFRGYLDD PRNTDNSWIE
     TRAVNIHLDS EEKLSRFLKN VNESSSGGSL RWQILDHKIP IYADEKEILQ RTAELHGTHY
//