ID A0A1L8HC98_XENLA Unreviewed; 556 AA.
AC A0A1L8HC98;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Transmembrane protease serine 2 isoform X1 {ECO:0000313|RefSeq:XP_041437449.1, ECO:0000313|RefSeq:XP_041437450.1};
GN Name=tmprss2.2.L {ECO:0000313|RefSeq:XP_041437449.1,
GN ECO:0000313|RefSeq:XP_041437450.1, ECO:0000313|RefSeq:XP_041437451.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041437451.1};
RN [1] {ECO:0000313|RefSeq:XP_041437449.1, ECO:0000313|RefSeq:XP_041437450.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041437449.1,
RC ECO:0000313|RefSeq:XP_041437450.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041437449.1,
RC ECO:0000313|RefSeq:XP_041437450.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR RefSeq; XP_041437449.1; XM_041581515.1.
DR RefSeq; XP_041437450.1; XM_041581516.1.
DR RefSeq; XP_041437451.1; XM_041581517.1.
DR STRING; 8355.A0A1L8HC98; -.
DR PaxDb; 8355-A0A1L8HC98; -.
DR KEGG; xla:495248; -.
DR OMA; HENWSEN; -.
DR OrthoDB; 5577980at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 3.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF11; TRANSMEMBRANE SERINE PROTEASE 2; 1.
DR Pfam; PF15494; SRCR_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00202; SR; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS50287; SRCR_2; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|RuleBase:RU363034};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|RefSeq:XP_041437449.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 65..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 213..253
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 320..553
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DISULFID 115..130
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 157..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 197..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 556 AA; 60727 MW; C96EBC8FD29F0C1C CRC64;
MDPNVYVVPP SYNEYELPPP PLYEPVPYTI PVKPPPPPYS SEVNTAQFGA GPPTRSSSWT
HKKKICLISA TVVCTVVAIG AALIIGFLVT KPSNTATCQI RCAYSSKCIS PYQICDGTYD
CIFGTDEDNC VTKSPSNPTC QIYCIYTFKC IYGYQICDGI RDCTYGDDEN NCVTTRPTYC
EKSCGSSPSC VLSSQWCDGV TQCPNGEDEM SCVRLYGADF QLQVYSPLKS AWLPVCSNNW
NNDYGKLACQ DFGYSRSSYN RSDTLPSTYS PNGYFQLNNG SWSSKFYTNV QYSSSCFSGN
VVSLRCIRCG VSNNNVASRI VGGTNAALGN WPWQVSLRHS SGILCGGSII SPKWIVTAAH
CVYGSSGIAS DWKVFAGLLN LSNYYDSNGH LVEKIIAHPG YKDSNKDKDI ALMKLRDEIT
FGYNTQPVCL PNSGMFWNAG TSCWISGWGT TSEKGTVSTT LKNAEVPLID SKVCNQSSMY
NGEITSSMIC AGYRSGGVDT CQGDSGGPLV TKTSSIWWLV GDTSWGYGCA RVNKPGVYGN
MTTFLEWIYL QTRINS
//
