ID A0A1L8HDX1_XENLA Unreviewed; 296 AA.
AC A0A1L8HDX1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Adapter molecule crk {ECO:0000256|ARBA:ARBA00039213};
GN Name=crk.L {ECO:0000313|RefSeq:XP_018100409.1,
GN ECO:0000313|Xenbase:XB-GENE-996363};
GN Synonyms=crk {ECO:0000313|RefSeq:XP_018100409.1}, crk2
GN {ECO:0000313|RefSeq:XP_018100409.1}, crkII
GN {ECO:0000313|RefSeq:XP_018100409.1}, v-crk
GN {ECO:0000313|RefSeq:XP_018100409.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018100409.1};
RN [1] {ECO:0000313|RefSeq:XP_018100409.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018100409.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018100409.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the CRK family. {ECO:0000256|ARBA:ARBA00009756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_018100409.1; XM_018244920.2.
DR AlphaFoldDB; A0A1L8HDX1; -.
DR GeneID; 398951; -.
DR AGR; Xenbase:XB-GENE-996363; -.
DR CTD; 398951; -.
DR Xenbase; XB-GENE-996363; crk.L.
DR OMA; KMNVNGQ; -.
DR OrthoDB; 2900795at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 398951; Expressed in blastula and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:2000145; P:regulation of cell motility; IEA:UniProt.
DR CDD; cd09926; SH2_CRK_like; 1.
DR CDD; cd11759; SH3_CRK_C; 1.
DR CDD; cd11758; SH3_CRK_N; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035458; CRK_SH3_C.
DR InterPro; IPR035457; CRK_SH3_N.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19969:SF8; ADAPTER MOLECULE CRK; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
SQ SEQUENCE 296 AA; 33398 MW; 50A2D156D14A0B31 CRC64;
MAGNFDSEDR ASWYWGKQNR QEAVNLLQGQ RHGVFLVRDS TTIPGDYVLS VSENSKVSHY
IINSVSNNRQ SSTGMVQSRF RIGDQEFDSL PTLLEFYKIH YLDTTTLIEP VSKSKQSGVI
QRQEEVEYVR ALFDFIGNDD EDLPFKKGDI LRIREKPEEQ WWNAEDSDGR RGMIPVPYVE
KYRPPSSAGS ALIGGNQENS HPQPLGGPEP GPYAQPSVNT PLPNLQNGPI FARVIQKRVP
NAYDKTALAL EVGDLVKVTK INVSGQWEGE CNGKYGHFPF THVRLLDQQN PEEDFS
//
