ID A0A1L8HJ25_XENLA Unreviewed; 567 AA.
AC A0A1L8HJ25;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=APC membrane recruitment protein 2 {ECO:0000256|ARBA:ARBA00039511};
DE AltName: Full=Protein FAM123A {ECO:0000256|ARBA:ARBA00042108};
GN Name=amer2.L {ECO:0000313|RefSeq:XP_018103210.1,
GN ECO:0000313|Xenbase:XB-GENE-17344612};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018103210.1};
RN [1] {ECO:0000313|RefSeq:XP_018103210.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018103210.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018103210.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator of the canonical Wnt signaling pathway
CC involved in neuroectodermal patterning. Acts by specifically binding
CC phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to
CC the cell membrane and interacting with key regulators of the canonical
CC Wnt signaling pathway, such as components of the beta-catenin
CC destruction complex. {ECO:0000256|ARBA:ARBA00037665}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the Amer family.
CC {ECO:0000256|ARBA:ARBA00007750}.
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DR RefSeq; XP_018103210.1; XM_018247721.2.
DR AlphaFoldDB; A0A1L8HJ25; -.
DR STRING; 8355.A0A1L8HJ25; -.
DR PaxDb; 8355-A0A1L8HJ25; -.
DR GeneID; 108708715; -.
DR KEGG; xla:108708715; -.
DR AGR; Xenbase:XB-GENE-17344612; -.
DR CTD; 108708715; -.
DR Xenbase; XB-GENE-17344612; amer2.L.
DR OMA; VPHKEDP; -.
DR OrthoDB; 5356638at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 108708715; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019003; AMER.
DR PANTHER; PTHR22237:SF1; APC MEMBRANE RECRUITMENT PROTEIN 2; 1.
DR PANTHER; PTHR22237; UNCHARACTERIZED; 1.
DR Pfam; PF09422; AMER; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ SEQUENCE 567 AA; 61351 MW; 1EA1F01C4CD6D40B CRC64;
MDLHYDCAES PAVEQPSGKI NKTAFKLFGK RKSGSAMPTI FGVKNKGDGK GTGKIGMVRS
KTLDGLADVV LESNKKEELC TETGASQLNP EKSPTVVTIN ADVSPNSSVA KSHSFFSLLK
KNGKSENVKG EQAEQKPGSR QKRGLKGLFN SMRWSKKDKS YKDDKEGASE SQPGLILPSS
LTASLECIKE ETQKPLCEKG KSNEDIPADV PSVEHSRDVN TSAEENPLKA SEESLCSTLI
TEEPQLEDPP VIQHVDNLCQ LPDPEVETLP DNKEEDVTGC GDVIADQDDD GGSSTGSKVV
PGNGKKVPSN KNTNIVVYQG GGEEMASPEQ VDETYVQELF SMVPQSEGAS EKTEKVNGTT
QVTSREVKCS DSGHDRKGVK PSKLRQVPIY RKERGDQNSK GNEKRQCLRN SDEGYWDSTT
PGQEEEEPRS VGKQALARDS CSGDALYDLY TDPDESIHKA QAEDPPVSHS HSKPLSPVTT
SCPVKTSSSN KESKIPISIK HLPVHTTNQG TDSGSGSASG HPHPVKSELP RTKIPVSKVL
VRRVSNKVIT ETAAGKRAIH DPTRKYH
//
