ID A0A1L8HJR7_XENLA Unreviewed; 559 AA.
AC A0A1L8HJR7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=trim39l.L {ECO:0000313|Xenbase:XB-GENE-22167850};
GN Synonyms=trim39l.1.L {ECO:0000313|RefSeq:XP_018103325.1,
GN ECO:0000313|RefSeq:XP_018103326.1, ECO:0000313|RefSeq:XP_041438804.1,
GN ECO:0000313|RefSeq:XP_041438805.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018103326.1};
RN [1] {ECO:0000313|RefSeq:XP_018103325.1, ECO:0000313|RefSeq:XP_018103326.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018103325.1,
RC ECO:0000313|RefSeq:XP_018103326.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018103325.1,
RC ECO:0000313|RefSeq:XP_018103326.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR RefSeq; XP_018103325.1; XM_018247836.2.
DR RefSeq; XP_018103326.1; XM_018247837.2.
DR RefSeq; XP_018103327.1; XM_018247838.1.
DR RefSeq; XP_041438804.1; XM_041582870.1.
DR RefSeq; XP_041438805.1; XM_041582871.1.
DR PaxDb; 8355-A0A1L8HJR7; -.
DR GeneID; 108708800; -.
DR KEGG; xla:108708800; -.
DR AGR; Xenbase:XB-GENE-22167850; -.
DR CTD; 108708800; -.
DR Xenbase; XB-GENE-22167850; trim39l.L.
DR OMA; VAYNCIN; -.
DR OrthoDB; 3088759at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 108708800; Expressed in spleen and 18 other cell types or tissues.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR CDD; cd19769; Bbox2_TRIM16-like; 1.
DR CDD; cd16597; RING-HC_TRIM25_C-IV; 1.
DR CDD; cd12891; SPRY_PRY_C-I_2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465:SF39; B BOX AND SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 12..55
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 140..176
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 335..559
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 191..283
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 559 AA; 63226 MW; B4AA368161B418B0 CRC64;
MAAADVIDEL SCSICLILYT DPVMLPCGHN FCQGCIEKVL DTQEGSGAYS CPECRQEYEE
RPALPRNRTL GNIAERFRPT ETQLGETGIF CTYCVLSPVP AAKSCLLCEA SLCDTHLRGH
SQSHKHILTA PTRSFGERKC PQHDELLTYY CHGESVCVCV YCAGFGQHKG HNVEPLKEAF
EKMMIQLRQV LEKLPIKREE TEGQIQRLQE RRREVAEKAA GETERVTALF RDIREQLEAL
EKRLLSDISS QKEKLSLPLT NLIRELEIKK EKLGEKMRHI EELCNMADPF SLLKKLESEG
ADVWENDCRD IGGKESDDGK LHDENDLHEV LIMNPIYRGL GDIVTRAKRR LGNESIIMDR
NTAHKDLTIS TDAKSASYSG SSVKQGYSSY PGSYINQGYY NQSQTFQVYS ANQAYTVKNF
QFQTQVLSTM CFHIGQHYWD VDYSKSEQLR VGVAYPSIER GGYSNIGNDN KSWELGIVQS
SYNTSSFSVL HGGIETSLSF PQGRSPINQI RVYLDYEAGR LSFYELSEPI RHLHTFTATF
TEPLHALFWV GKGSVTVID
//
