ID A0A1L8HKR1_XENLA Unreviewed; 658 AA.
AC A0A1L8HKR1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Carboxypeptidase Z {ECO:0000313|RefSeq:XP_018098514.1};
GN Name=cpz.S {ECO:0000313|RefSeq:XP_018098514.1,
GN ECO:0000313|Xenbase:XB-GENE-6487274};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018098514.1};
RN [1] {ECO:0000313|RefSeq:XP_018098514.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018098514.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018098514.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR RefSeq; XP_018098514.1; XM_018243025.2.
DR AlphaFoldDB; A0A1L8HKR1; -.
DR STRING; 8355.A0A1L8HKR1; -.
DR PaxDb; 8355-A0A1L8HKR1; -.
DR GeneID; 108706528; -.
DR KEGG; xla:108706528; -.
DR AGR; Xenbase:XB-GENE-6487274; -.
DR CTD; 108706528; -.
DR Xenbase; XB-GENE-6487274; cpz.S.
DR OMA; CARAFES; -.
DR OrthoDB; 5490979at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 108706528; Expressed in neurula embryo and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd03867; M14_CPZ; 1.
DR CDD; cd11308; Peptidase_M14NE-CP-C_like; 1.
DR Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR034239; M14_CPZ_CPD.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR11532:SF63; CARBOXYPEPTIDASE Z; 1.
DR PANTHER; PTHR11532; PROTEASE M14 CARBOXYPEPTIDASE; 1.
DR Pfam; PF13620; CarboxypepD_reg; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR PRINTS; PR00765; CRBOXYPTASEA.
DR SMART; SM00063; FRI; 1.
DR SMART; SM00631; Zn_pept; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00133; CARBOXYPEPT_ZN_2; 1.
DR PROSITE; PS50038; FZ; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000313|RefSeq:XP_018098514.1};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Hydrolase {ECO:0000313|RefSeq:XP_018098514.1};
KW Protease {ECO:0000313|RefSeq:XP_018098514.1};
KW Receptor {ECO:0000256|ARBA:ARBA00023040};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT DISULFID 122..146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 658 AA; 74521 MW; 83726C49EE514FFA CRC64;
MPTALLLLLL AACCWHVHCS PNCHPGDRAL GRCMPTAEER GTCVDNILGY CNDLPYSKTM
FPNALDQQSR GEIEFSAEYI LLSVIHNLLQ GECNPDLRIV GCAVLAPRCE KNKMVKPCRR
VCETLKKNCL PAFNAIDMAW PYFLDCDRFF VGGEEECHDP LEKLRANIEI TSEDLLPETP
STFIQFVHHS YSEMVRVLKK TAAKCSQVSK TYSLGRSYEG KELLVIEFSA NPGQHKAMTP
EFRYIGNMHG NEVAGRELLI YLAQFLCSEY LLGNSRIQTL INTTRIHLLP SMNPDGYEHA
AEEGAGYNGW TNGRLNAQNI DLNRNFPDLT SEAHKIIRMP LARLDHMPIP ESYWDNKIAP
ETKAVMKWSR SIPFVISGSL HGGDLVVSYP YDFSRHPLEE KMFSPTPDEK VFQMLAKTYV
AAHPVMSDKS TGRCGGNFNS KGGIINGAEW YSFSGGMADF SYLHTNCFEL TLELGCEKFP
TEDELYSIWQ NNKEAMLSLI EMVHRGIKGI VKDEHGNPIK KARISVRGIR HDITTGEDGD
YFRLLIPGSY IVSAEAFGYS KVTKKITLPA KMLKAGHVDF VLKRVEVRNR KFPKVIPEDI
YERFDPLDRF NPHAQHEGAE PSEGEEASSR NGEKPWWWSY FSMLGHNRPS WLLKNEEN
//