ID A0A1L8HLS2_XENLA Unreviewed; 383 AA.
AC A0A1L8HLS2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=POU domain protein {ECO:0000256|RuleBase:RU361194};
GN Name=pou4f2.S {ECO:0000313|Xenbase:XB-GENE-17344193};
GN Synonyms=LOC108706667 {ECO:0000313|RefSeq:XP_018098765.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018098765.1};
RN [1] {ECO:0000313|RefSeq:XP_018098765.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018098765.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018098765.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family.
CC {ECO:0000256|RuleBase:RU361194}.
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DR RefSeq; XP_018098765.1; XM_018243276.2.
DR AlphaFoldDB; A0A1L8HLS2; -.
DR STRING; 8355.A0A1L8HLS2; -.
DR PaxDb; 8355-A0A1L8HLS2; -.
DR GeneID; 108706667; -.
DR KEGG; xla:108706667; -.
DR CTD; 108706667; -.
DR Xenbase; XB-GENE-17344193; pou4f2.S.
DR OMA; PFAMAHT; -.
DR OrthoDB; 4250502at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 108706667; Expressed in brain and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR PANTHER; PTHR11636; POU DOMAIN; 1.
DR PANTHER; PTHR11636:SF41; POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transcription {ECO:0000256|RuleBase:RU361194}.
FT DNA_BIND 319..378
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 383 AA; 41624 MW; 75D10A39D30B7BB1 CRC64;
MMMMSLSSKQ PFSMSHSSMQ DPETKYSALH SSSPHSSSSA TSSPSISRAG AGSGSSNSNS
SAEAMRRACL PTPPSNIFGG LDESLLARAE ALAAVDLVSQ CKSQHHHHHH HTPHHSPFKP
DATYHTMNTI PCTSASSSVP ISHPSGVTGS HHHHHHHHHH QPLEGELLDH ITPGLTLGAL
TGPDGSVVST PAHPHMASMN PMHQAALSMA HAHGLPTHMG CMSDVDADPR DLEAFAERFK
QRRIKLGVTQ ADVGSALANL KIPGVGSLSQ STICRFESLT LSHNNMIALK PILQAWLEEA
EKSHRDKLTK PELFNGAEKK RKRTSIAAPE KRSLEAYFSI QPRPSSEKIA AIAEKLDLKK
NVVRVWFCNQ RQKQKRMKYS AGI
//
