ID A0A1L8HN13_XENLA Unreviewed; 653 AA.
AC A0A1L8HN13;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Phosphate transporter {ECO:0000256|RuleBase:RU363058};
GN Name=slc20a2.S {ECO:0000313|RefSeq:XP_018099034.1,
GN ECO:0000313|RefSeq:XP_041435785.1,
GN ECO:0000313|Xenbase:XB-GENE-17333841};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_041435785.1};
RN [1] {ECO:0000313|RefSeq:XP_018099034.1, ECO:0000313|RefSeq:XP_041435785.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018099034.1,
RC ECO:0000313|RefSeq:XP_041435785.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018099034.1,
RC ECO:0000313|RefSeq:XP_041435785.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sodium-phosphate symporter. {ECO:0000256|RuleBase:RU363058}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in);
CC Xref=Rhea:RHEA:71259, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474;
CC Evidence={ECO:0000256|ARBA:ARBA00035083};
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363058}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363058}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000256|ARBA:ARBA00009916,
CC ECO:0000256|RuleBase:RU363058}.
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DR RefSeq; XP_018099034.1; XM_018243545.2.
DR RefSeq; XP_041435785.1; XM_041579851.1.
DR STRING; 8355.A0A1L8HN13; -.
DR PaxDb; 8355-A0A1L8HN13; -.
DR GeneID; 108706816; -.
DR KEGG; xla:108706816; -.
DR AGR; Xenbase:XB-GENE-17333841; -.
DR CTD; 108706816; -.
DR Xenbase; XB-GENE-17333841; slc20a2.S.
DR OMA; AAMICIG; -.
DR OrthoDB; 5488632at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 108706816; Expressed in muscle tissue and 18 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PHOSPHATE TRANSPORTER; 1.
DR PANTHER; PTHR11101:SF80; SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 2; 1.
DR Pfam; PF01384; PHO4; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363058};
KW Phosphate transport {ECO:0000256|ARBA:ARBA00022592,
KW ECO:0000256|RuleBase:RU363058};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Sodium {ECO:0000256|ARBA:ARBA00023201};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363058};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363058};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363058}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 117..138
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 144..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 185..207
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 213..239
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 486..505
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 535..552
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 619..645
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
SQ SEQUENCE 653 AA; 70503 MW; 16BEB37D82B7F3FA CRC64;
MVLDEYLWMV IVGFIIAFVL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETTGSV
LLGAKVGETI RKGIIDVNLY NNTVDLLMAG EVSAMVGSAV WQLIASFLKL PISGTHCIVG
ATIGFSLVAI GTHGVQWMQL VKIVASWFIS PLLSGLMSGA LFLMIKFFIL NKEDPVPNGL
KALPVFYAAT IGINVFSILF TGAPLLGLQS FPVWGTALLS IGIAIIFALV VWFLVCPWMK
KKIASRLKKE GAMLGISEES LDKIQDEETS VFKELPGAKG NDESVLPLTS SSTEVAVASD
SVSNGNTRVP YGRAASMTNG SIRSPISNGT FNFDGHTVKS DAHVYHTVHK DSGLYKDLLH
NIHLDRVKVD RPAADNNYRV LRRNNSYTCY TAAICGVPVH STFKSSDVAM PEDSEKLVGD
TVSYSKKRVR YDSYSSYCNA VAEAEIEAEE GGIEMKLATE LADPNPPQDD SLEEDKEEKE
KSEVHLLFHF LQILTACFGS FAHGGNDVSN AIGPLVALWL IYQQGGVMQE ASTPVWLLLY
GGVGICAGLW VWGRRVIQTM GKDLTPITPS SGFTIELASA FTVVVASNIG LPISTTHCKV
GSVVAVGWIR SRKAVDWHLF RNIFLAWFVT VPVAGLFSAG VMAIFQYGIL PYV
//
