ID A0A1L8HP35_XENLA Unreviewed; 338 AA.
AC A0A1L8HP35;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN Name=zdhhc21.S {ECO:0000313|RefSeq:XP_018099285.1,
GN ECO:0000313|Xenbase:XB-GENE-17337660};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018099285.1};
RN [1] {ECO:0000313|RefSeq:XP_018099285.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018099285.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018099285.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|ARBA:ARBA00023340};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC Evidence={ECO:0000256|ARBA:ARBA00023340};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
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DR RefSeq; XP_018099285.1; XM_018243796.2.
DR AlphaFoldDB; A0A1L8HP35; -.
DR STRING; 8355.A0A1L8HP35; -.
DR PaxDb; 8355-A0A1L8HP35; -.
DR GeneID; 108706949; -.
DR KEGG; xla:108706949; -.
DR AGR; Xenbase:XB-GENE-17337660; -.
DR CTD; 108706949; -.
DR Xenbase; XB-GENE-17337660; zdhhc21.S.
DR OrthoDB; 6683at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 108706949; Expressed in egg cell and 19 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR22883:SF473; PALMITOYLTRANSFERASE; 1.
DR PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU079119}; Membrane {ECO:0000256|RuleBase:RU079119};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 138..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 310..329
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 89..207
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
SQ SEQUENCE 338 AA; 38975 MW; 2CE6E6BCCA23862C CRC64;
MGLSLHFVVD PQGWCCVGAI FFIWLYNTLF VPKLILFPRF EEGQISVAAI LAYYLTSIFC
VISLLRASIA DPGKLQDSPK IPLTEKELWE LCNKCNMMRP KRSHHCSRCG HCVRRMDHHC
PWINNCVGED NHWLFLQLCF YTQLLSGYTL VLDFCHYYYF LPLKAINWDM VIFRHELALL
RISTFMGIVM FGGMCSLFYT QIMGILTIEG SKAMAADLLR SFWHSLEDPV VHSFQAEATT
ASLLLLCQSR LNRWMVGTDG FAMLEASYRF YHNSAMTVFK SIIIHPPIFD ITKCPRLFFN
SDLNAVVGNC IRYVFVLTLI SFFCCPFPLR TRLPQATN
//
