ID A0A1L8HPF5_XENLA Unreviewed; 459 AA.
AC A0A1L8HPF5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Nuclear factor interleukin-3-regulated protein {ECO:0000256|ARBA:ARBA00018259, ECO:0000256|PIRNR:PIRNR019029};
GN Name=nfil3.S {ECO:0000313|Xenbase:XB-GENE-17345002};
GN Synonyms=LOC108707002 {ECO:0000313|RefSeq:XP_018099376.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018099376.1};
RN [1] {ECO:0000313|RefSeq:XP_018099376.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018099376.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018099376.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May act as a transcriptional regulator of a number of
CC proteins of the circadian clock. {ECO:0000256|PIRNR:PIRNR019029}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR019029}.
CC -!- SIMILARITY: Belongs to the bZIP family. NFIL3 subfamily.
CC {ECO:0000256|ARBA:ARBA00006079, ECO:0000256|PIRNR:PIRNR019029}.
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DR RefSeq; XP_018099376.1; XM_018243887.2.
DR AlphaFoldDB; A0A1L8HPF5; -.
DR STRING; 8355.A0A1L8HPF5; -.
DR PaxDb; 8355-A0A1L8HPF5; -.
DR GeneID; 108707002; -.
DR KEGG; xla:108707002; -.
DR CTD; 108707002; -.
DR Xenbase; XB-GENE-17345002; nfil3.S.
DR OMA; PVDMTSK; -.
DR OrthoDB; 4467729at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 108707002; Expressed in muscle tissue and 16 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007623; P:circadian rhythm; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14694; bZIP_NFIL3; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR047229; NFIL3-like.
DR InterPro; IPR047106; NFIL3-like_bZIP.
DR InterPro; IPR016743; NFIL3/E4BP4.
DR InterPro; IPR010533; Vert_IL3-reg_TF.
DR PANTHER; PTHR15284; NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN; 1.
DR PANTHER; PTHR15284:SF1; NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN; 1.
DR Pfam; PF07716; bZIP_2; 1.
DR Pfam; PF06529; Vert_IL3-reg_TF; 1.
DR PIRSF; PIRSF019029; bZIP_E4BP4; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|PIRNR:PIRNR019029};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108,
KW ECO:0000256|PIRNR:PIRNR019029};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR019029};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR019029};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|PIRNR:PIRNR019029};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR019029};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR019029}.
FT REGION 258..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 51543 MW; CD64E1B713513C61 CRC64;
MQLTKMPTIK REQECADSRM ENILVLSSNI PDMSESMDSS NDMLYSDGLN VKNKSSSCRR
KREFIPDEKK DAMYWEKRRK NNEAAKRSRE KRRLNDVVLE NKLMVLGEEN ASLKTELLSL
KLKFGLISST SYAQEIQKVT SSTAVFFQEY SSSKPNMSYN SDHEHSVMTS SCISVIKHSP
QSSLSDVSEA SSMEHVQPST IQSNCRSTDI KFQRVKREPV EVENFSRDAR EDSNTFQGSI
YANYIGSTFP GYSHSPPLVH INRSSSNSPR TSEADEGVVG KTSDGEDEQR VPKGPIHSPV
ELKNGHTTII KVPEVNSSAL PHKLRIKAKA MQIKVEALES ELDSTQKLTL PIDMSSKRHL
QLEKHNSENM VHSSLSPLSV QVTNIQDWPL KPGQWHHREL DKMPSLCKTS GIVHIKDNVY
KAPESESLYL KQGIATLSAE VASLKRLIVT QEICASNSS
//
