ID A0A1L8HQZ9_XENLA Unreviewed; 1142 AA.
AC A0A1L8HQZ9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Solute carrier family 12 member 2 isoform X2 {ECO:0000313|RefSeq:XP_018099760.1};
GN Name=slc12a2.S {ECO:0000313|RefSeq:XP_018099760.1,
GN ECO:0000313|Xenbase:XB-GENE-17345824};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018099760.1};
RN [1] {ECO:0000313|RefSeq:XP_018099760.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018099760.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018099760.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_018099760.1; XM_018244271.2.
DR AlphaFoldDB; A0A1L8HQZ9; -.
DR STRING; 8355.A0A1L8HQZ9; -.
DR PaxDb; 8355-A0A1L8HQZ9; -.
DR GeneID; 108707193; -.
DR KEGG; xla:108707193; -.
DR AGR; Xenbase:XB-GENE-17345824; -.
DR CTD; 108707193; -.
DR Xenbase; XB-GENE-17345824; slc12a2.S.
DR OMA; WLDIMTR; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 108707193; Expressed in internal ear and 18 other cell types or tissues.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00023201}.
FT DOMAIN 149..200
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 236..736
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 745..1142
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1142 AA; 125167 MW; B6CD78A237A61C74 CRC64;
MEQAGKPGSG QTEQGKSPSS SLNPQPSQTA SPSGQDLLVD DTQAGRPMGP TPSQSRFQVD
LVTEGSKEAA AQELQQQEDG VKQRCRGGSG SDEAKGRFRV NFVDPAAPEG ISPENADGGS
GGVSFQNGDT VLSEGSLHSG GTGHHYHYDT HTNTYYLRTF GHNTIDAVPR IDYYRHTAAD
LGEKLLRPSL AELHDELDKE PFEDGFANGE DGTPTGDAVT NVADSKGVVK FGWIKGVLVR
CMLNIWGVML FIRMSWIVGQ AGIGLTIVVI AMATVVTTIT GLSTSAIATN GFVRGGGAYY
LISRSLGPEF GGAIGLIFAF ANAVAVAMYV VGFAETVVEI LKENGALMVD QFNDIRIIGA
ITVVLLLGIS VAGMEWEAKA QIVLLVILLL AIGDFFIGTV IPSEEKKPKG FFGYKADIFS
ENFGPDFRGE TFFSVFAIFF PAATGILAGA NISGDLADPQ HAIPRGTLLA ILITTVVYIG
VAVSVGSCVV RNASGDVNST LSASMTNCTT AACNLNYDFS SCGQDCKYGL MENFQVMSMV
SGFAPLITAG IFSATLSSAL ASLVSAPKVF QALCKDNIYP GLQMFAKGYG KNNEPLRGYI
LTFLIALGFI LIAELNLIAP IISNFFLASY ALINFSVFHA SLAKSPGWRP AFRYYNMWVS
LIGALLCCGV MFVINWWAAL LTYVIVIGLY IYVTYKKPDV NWGSSTQALT YLNALQHTIR
LSGVEDHVKN FRPQCLVLIG APNSRPALLH LVHAFTKNVG LMICGHVHMG PRRQAMKELL
TDQARYQRWL IKNKTKAFYS PVHAEDLRDG AQYLMQAAGL GRMRPNILVV GFKKNWSQCD
MREVETYINL FHDAFDFQYG VVVIRLKEGL DISHLQGQEE LLSSQEKSPG TKDVVVNVDY
SKKAEAEASR PFASDSSPMM RKDCKGQGIS LDTADQRLLD ASLQFQKKQG KSTIDVWWLF
DDGGLTLLIP YLITTKKKWR DCKIRVFIGG KINRIDHDRR AMATLLSKFR IDFSDIMVLG
DINTKPKKEN VAAFEEMIEP FRLHEDEKEQ EVADKMKEEE PWRITDNELE LYKTKTHRQI
RLNELLKEHS STANVIVMSL PVARKGAVSS ALYMAWTEAL SKDLPPILLV RGNHQSVLTF
YS
//
