ID A0A1L8HRJ1_XENLA Unreviewed; 2332 AA.
AC A0A1L8HRJ1;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=mast4.S {ECO:0000313|RefSeq:XP_018099958.1,
GN ECO:0000313|Xenbase:XB-GENE-6487414};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018099958.1};
RN [1] {ECO:0000313|RefSeq:XP_018099958.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018099958.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018099958.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00009903}.
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DR RefSeq; XP_018099958.1; XM_018244469.2.
DR STRING; 8355.A0A1L8HRJ1; -.
DR PaxDb; 8355-A0A1L8HRJ1; -.
DR GeneID; 108707281; -.
DR KEGG; xla:108707281; -.
DR AGR; Xenbase:XB-GENE-6487414; -.
DR CTD; 108707281; -.
DR Xenbase; XB-GENE-6487414; mast4.S.
DR OMA; PLSAHAX; -.
DR OrthoDB; 2915765at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 108707281; Expressed in zone of skin and 17 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd05609; STKc_MAST; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.1480.20; MAST3 pre-PK domain-like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR037711; MAST.
DR InterPro; IPR015022; MAST_pre-PK_dom.
DR InterPro; IPR023142; MAST_pre-PK_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24356:SF224; MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 4; 1.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF08926; DUF1908; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF140482; MAST3 pre-PK domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_018099958.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 2332 AA; 255781 MW; BD831B12C5C8E9C5 CRC64;
MERKVLECEG AGNGSDRSSS SSLSSSGSQT LSEGNMKRAQ SGGSSSSTDC ESGRRRDRRQ
EGRDHSGAEE ELDSILSPPS MLSRKCSNPE VSVRPCKSVK YKSQLSDDGR ILRRGSLGGA
LTGRYLLPAG ATQQIWPTST EASNLVRMRS QALGQSAPSL TASLKELSLP RRGSFCRTSN
RKSLIGSNQS PALPRPHSPL SAHTGSSPQD SPRNFSPSAS AHFSFARRTD GRRWSLASLP
SSGYGTNTPS STVSSSCSSQ EKLHQLPYQP TPDELHFLSR HFCTESIAID DRCRTTPLRP
RSRSLSPGRT LACCDHEIIM MNHVYKERFP KATAQMEERL QDIITNYSPD SVLPLADGVL
SFTHHQIIEL ARDCLDKSNL GLITSRYFLE LQQKIEKLLH EAYERSESGE LAFIKQLVQK
ILIVIARPAR LLECLEFDPE EFYYLLEAAE GHAKEGQGIK TDIPRYIISQ LGLNKDPLEE
IALLSNYDSG TAETPETDES ISSSKKSMKI RRKPCESDFE AMKLISNGAY GAVYLVRHKE
TRQRFAMKKI NRQNLILRNQ IQQAFVERDI LTFAENPFVV SMYCSFETRR HLCMVMEYVE
GGDCATLLKN IGPLPVDMAR MYFAETVLAL EYLHNYGIVH RDLKPDNLLV TSMGHIKLTD
FGLSKVGLMN MTTNLYEGHI EKDAREFLDK QVCGTPEYIA PEVILRQGYG KPVDWWAMGI
ILYEFLVGCV PFFGDTPEDL FGQVIIDEIN WPEKEDAPPS DAQDLITLLL RQNPLERMGT
GGAYEVKQHS FFCALDWNSL LRQKAEFIPQ LESEDDTSYF DTRSEKYHHM ETEEEDDTND
EDFSMEIRQF SSSSHRFSKV FSSIDQLMQS KVEEKDDSTD KSKDLSLPPV ESLSWSSEYS
EMQQLSISTC SETENQKPCH NGSLLPKFAI SSDIERDELC SGGPKATDHS TQEPEDSLQE
DLDVTTPISI SSSTVSDVYS VSPLGSPISP LSMSSDASSR DSSPSRESSI SSSSPKQPII
IQSSGKKFGF TLQAIRVFVG DSDIYTVHHI VWSVEEGSAA YQAGLKAGDL ITHINGEPVH
GLVHTEVIEL LLKSGSKVAI MTTAFEDTSI KTGPARRNSY KSRMVRRTKK TKKKENIERR
RSFFKKLAKQ PSPLLHTSRS FSCLNRSLSS GESLPASPTH SLSPRSPTPS CRSTPDFPSG
TNSSQSSSPS SSAPNSPAGS GHIRPSTLHG LGPKLGSQRY RSGRRKSAGS IPLSPLARTP
SPTPQPPSPQ RSPSPLHSHS VGNTKATPSF PAKMHSPPTI VRHVVRPKSA EPPRSPLLKR
VQSEEKLSPS YCCEKKHLCS RKHNLEVTKE EIHKQTLQRE LALQSLEENI CDVLSCTRIK
PVEQGCLKRP VSRKVGRQES LDELDKEKLK AKIVMKKKDM PERQDSLLKQ SLMHDLHNEL
GSPITVAEQE KEDKSYQNLI KRTNLSEHRL TTYESRGGIM FKDTLNKGVI SRTNGGFMDG
QLHGHGPQAA ENVHISCEIK KASSSCDRVV LARDDNVDKA SSACTANSEL LRKKKSLEEK
ESTLCLVLKS KAHESIQAKS SFLPTESIAP LDNRTCLPNA QSSTVSFAPL KASNNRCENN
NDKSGVLHTE TSVRKSPSEF KLEARSVSSL KPIEGTLDIA LLSGPKVTKT EYTDIALEKK
NQNVAKAEKI SPDSKNDVVH KPDNQNMFLF SNTSAGGVSL HSAHKRPIKE NPKECPQSNL
AAAEICSNKE VSGLKEKNEL QNQAAGSAQS GLKESSAQEL ATSARRNGQE MKSSLVSTGR
CSLEQKQNKT CRAMTDPSQE PSGIRVEASL TKSSSPEKTD RALHATGGKS CQAPVSKLCP
NECVSVPKPA PVMDVDSPIL LNTKVDIKVK VAVKQEPSSV SSSSKTQEIT SILKAGSEKS
NRELSTNKES VSLKAQQYVA ESIFSGAVPE ASSKSSLHSQ KEQKLSHEQL NDSTGKSNIS
SSSTTKANSF GKSGVPEQPS TGALKKEMAI QRTNVLLKVD KGANILLSSL SQNKDIVISE
KTTNYFPSST VSTRNTSLSA TRETHSNSHQ ATSSACSSTP NPKECSAKSH LKEKTSLQPK
LTRTVTVKSG VQSKLSAEGL ALGMSSPEKQ QDSKCTEALY VQSDKRESKV MPTVTNRDTR
KVTEKPKSVN SPNVMGKGAQ NKTDLVDAHN GVSALSATVS SPNVDTSLTK PRLSECPLNI
STERNEITPN FVSSKAKKDV QLSPNKAGAK ADSIFSKSSA EKQFSFASNC VLSTANSRNQ
SLSPNKKNVA KDIQKAPPVS IGNPCALTSD KDLKGQKQGK DVLQTSPGEK TL
//
