ID A0A1L8HT91_XENLA Unreviewed; 595 AA.
AC A0A1L8HT91;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Hepatocyte growth factor activator {ECO:0000313|RefSeq:XP_018083875.1};
GN Name=hgfac.L {ECO:0000313|RefSeq:XP_018083875.1,
GN ECO:0000313|Xenbase:XB-GENE-6488461};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018083875.1};
RN [1] {ECO:0000313|RefSeq:XP_018083875.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018083875.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018083875.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00479}.
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DR RefSeq; XP_018083875.1; XM_018228386.2.
DR AlphaFoldDB; A0A1L8HT91; -.
DR STRING; 8355.A0A1L8HT91; -.
DR PaxDb; 8355-A0A1L8HT91; -.
DR GeneID; 108697902; -.
DR KEGG; xla:108697902; -.
DR AGR; Xenbase:XB-GENE-6488461; -.
DR CTD; 108697902; -.
DR Xenbase; XB-GENE-6488461; hgfac.L.
DR OMA; ETRYEYF; -.
DR OrthoDB; 4629979at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 108697902; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00061; FN1; 1.
DR CDD; cd00062; FN2; 1.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000083; Fibronectin_type1.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24264:SF43; HEPATOCYTE GROWTH FACTOR ACTIVATOR; 1.
DR PANTHER; PTHR24264; TRYPSIN-RELATED; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00039; fn1; 1.
DR Pfam; PF00040; fn2; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR PRINTS; PR00013; FNTYPEII.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00058; FN1; 1.
DR SMART; SM00059; FN2; 1.
DR SMART; SM00130; KR; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57440; Kringle-like; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01253; FN1_1; 1.
DR PROSITE; PS51091; FN1_2; 1.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DISULFID 116..133
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 135..144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 199..216
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 218..227
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 595 AA; 67283 MW; 8D67B31D971B10FE CRC64;
MDSLSRLSSL LAFLYCLTII AGALNKPRPL NLRPDGSHRF SHRALNLGQR MTEDGKKCKF
PFRFGGRVYF TCINRPPFYR KWCATTHNYD RDREWGYCSN VDRDVATQNY CAENPCEHGG
TCYNVAERGT YHCICPEGYT GTDCEKEKCF DHTHYEFYGI GESWPRIHSG RVESCTCFEG
NNIMCLGGAR YTACIENPCL NGGACRLMIS TGKTVCGCRG QHVGKYCDID IKQGCYDYDN
ATEYRGIKKN TQSGHSCLPW NSDMLYEEIH TGQEMNFISK GLGSHSYCRS PDDDEIPWCY
LMKDRLVSWE HCQIPKCSNK GRRVVMQEDA AVPAQPKCGK KHEKRVVARG RILGGNSALP
GAHPWIAGIY IGNYFCAGSL IHPCWVVSAA HCFADSPPKS KIHVVLGQQF FNQTTDVTQT
FEVERYIFYD KYSVFKRNEH DIVLIKLKRV NKMCAKKNQF VQTICLPNVN VPFTDDHHCQ
IAGWGRMHQD STEYAQNLQE AIVPLVPNNK CSSPEIYGAE ISENMFCAGY FDCTIDACQG
DSGGPLACEK DKISYLWGIV SWGDGCGSFN KPGVYTKVSN YVDWINRKIM PKKTD
//
