ID A0A1L8HWZ5_XENLA Unreviewed; 471 AA.
AC A0A1L8HWZ5;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Amino acid transporter {ECO:0000256|RuleBase:RU361216};
GN Name=LOC108713086 {ECO:0000313|RefSeq:XP_018111289.2};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018111289.2};
RN [1] {ECO:0000313|RefSeq:XP_018111289.2}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018111289.2};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018111289.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361216}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000256|RuleBase:RU361216}.
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DR RefSeq; XP_018111289.2; XM_018255800.2.
DR AlphaFoldDB; A0A1L8HWZ5; -.
DR STRING; 8355.A0A1L8HWZ5; -.
DR PaxDb; 8355-A0A1L8HWZ5; -.
DR KEGG; xla:108713086; -.
DR OMA; RKLGWYG; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:1902475; P:L-alpha-amino acid transmembrane transport; IEA:UniProt.
DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 1.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR11958:SF102; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR11958; SODIUM/DICARBOXYLATE SYMPORTER-RELATED; 1.
DR Pfam; PF00375; SDF; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF118215; Proton glutamate symport protein; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361216};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU361216};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361216};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361216};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361216}.
FT TRANSMEM 36..55
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 200..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 233..259
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 271..296
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 308..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 345..362
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
SQ SEQUENCE 471 AA; 51062 MW; EB173479D48B7A6E CRC64;
MGLLLNIQNS VLHLMSGLAT MDSKACGRMG LITITYYLWT TFLAVAVGII LVITIHPGSA
VHKEDYVGGK PVLSSADALL DLIRNMFPAN LIEASFQQYR TILVPVVKTQ TIPKSSGKSI
NFLYFAPDDI NPLIHRPVIL EVTPSPDIRY KTLPGTSTEM NVLGIVIFSA TIGLLLGKMG
DRGTPLVNVC LSLNEAVMKI VAVAVWYFPF GIVFLIAGKI LDMEEPSVIA KKLGMYTITV
MAGLFIHGVL LLPLLFLIIT RKNPFAFIQG ILHALLIALA TSSSSATLPI TMRCLIENNK
IDRRVARFVL PVGATINMDG TALYEAVAAI FIAQVNEYDL DLGQIITISI TATAASIGAA
GIPQSGLVTM VIVLTSVGLP TDDITLIVAV DWALDRFRTM TNVLGDALAA GVVAHVCKKD
FASYQEKQDQ VGKEEGSNIN EESVHADSHI MEMVEEAMYD KRRIQFNVCL V
//
