ID   A0A1L8I0Y1_XENLA        Unreviewed;       772 AA.
AC   A0A1L8I0Y1;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Microprocessor complex subunit DGCR8 {ECO:0000313|RefSeq:XP_018117637.1, ECO:0000313|RefSeq:XP_018117646.1};
GN   Name=dgcr8.S {ECO:0000313|Xenbase:XB-GENE-17339563};
GN   Synonyms=LOC108716057 {ECO:0000313|RefSeq:XP_018117637.1,
GN   ECO:0000313|RefSeq:XP_018117646.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018117637.1};
RN   [1] {ECO:0000313|RefSeq:XP_018117637.1, ECO:0000313|RefSeq:XP_018117646.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018117637.1,
RC   ECO:0000313|RefSeq:XP_018117646.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018117637.1,
RC   ECO:0000313|RefSeq:XP_018117646.1};
RG   RefSeq;
RL   Submitted (APR-2022) to UniProtKB.
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DR   RefSeq; XP_018117637.1; XM_018262148.2.
DR   RefSeq; XP_018117646.1; XM_018262157.2.
DR   RefSeq; XP_018117648.1; XM_018262159.1.
DR   STRING; 8355.A0A1L8I0Y1; -.
DR   PaxDb; 8355-A0A1L8I0Y1; -.
DR   GeneID; 108716057; -.
DR   KEGG; xla:108716057; -.
DR   CTD; 108716057; -.
DR   Xenbase; XB-GENE-17339563; dgcr8.S.
DR   OMA; ATVVCKN; -.
DR   OrthoDB; 5404886at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 108716057; Expressed in spleen and 19 other cell types or tissues.
DR   GO; GO:0070877; C:microprocessor complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031053; P:primary miRNA processing; IEA:InterPro.
DR   CDD; cd19867; DSRM_DGCR8_rpt1; 1.
DR   CDD; cd19868; DSRM_DGCR8_rpt2; 1.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 2.20.70.10; -; 1.
DR   Gene3D; 3.30.160.20; -; 2.
DR   Gene3D; 3.30.160.590; -; 1.
DR   InterPro; IPR040375; DGCR8.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR13482:SF3; MICROPROCESSOR COMPLEX SUBUNIT DGCR8; 1.
DR   PANTHER; PTHR13482; MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8; 1.
DR   Pfam; PF00035; dsrm; 2.
DR   SMART; SM00358; DSRM; 2.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR   SUPFAM; SSF51045; WW domain; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN          303..336
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          510..577
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          87..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..42
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..400
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   772 AA;  87180 MW;  F52F1B4A9F8238C6 CRC64;
     MEECEEVAPF PEVNGHDVTE MNPASPPPLP PEEEPPPPPL QTSSDAEVMD VGSGGDGQSQ
     TPAGELQQNN GLQLLTKGST SYKSHRTVLD PFHSDQSPRT ARHAPSNKRF TPDLKLLKDV
     KVSVSFTESC RSKDRHVLYT GLECEGSLHG GSNMNSVNGD MYVCPFAGSS NGNVTDSIEI
     TLKKNYEPEI DQEKKVEYAV LDELEDFTEN VMDVDEDGAE FVSESILQRD KIDEEALIYS
     YEDEFDNDVD ALLEESLHSP KKRRIEEKYD IDSDHQSDGE SSVQPMVTKI KTVLKSRGRP
     PTEPLPDGWI MTFHNSGLPV YLHRETRVVT WSRPYFLGTG SIRKHDPPIS SIPCLHYKKM
     KDNDIKEQSN DVTSALVSVS SSLKSSDTSH NSQEPDTTAA DSFVSDKRES VSEVAQGALG
     QVKAKVEVCK DESINLEDFR SYLEKRFDFE QVTVKKFRTW AERRQFNREI KRKQAECERP
     ILPANQKLIT LSVQDAPTKK EFVINPNGKS EVCILHEYMQ RVLKVRPVYN FFECENPSEP
     FGASVIIDGV TYGTGTASSK KLAKNKAARA TLEILIPDFV KQTCIEKPKD TDELEYFNHI
     SIEDSRVYEL TNKAGLLSPY QILHECLKRN HGMGDTSIKF EVIPGKNQKS EYVMTCGKHT
     VRGWCKNKRV GKQLASQKIL QLLHPYVKNW GSLLRMYGRE NSKIVKQETS DKSVIELQQF
     AKKNKPNLHI LNKLQEEMRR LAQEREETRK KPKMTIVESA QPGSEPLCTV DV
//