ID A0A1L8RF47_9ENTE Unreviewed; 312 AA.
AC A0A1L8RF47;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Mevalonate kinase {ECO:0000313|EMBL:OJG18353.1};
GN ORFNames=RU97_GL001750 {ECO:0000313|EMBL:OJG18353.1};
OS Enterococcus canis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=214095 {ECO:0000313|EMBL:OJG18353.1, ECO:0000313|Proteomes:UP000181884};
RN [1] {ECO:0000313|EMBL:OJG18353.1, ECO:0000313|Proteomes:UP000181884}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17029 {ECO:0000313|EMBL:OJG18353.1,
RC ECO:0000313|Proteomes:UP000181884};
RA Zhong Z., Sun Z., Liu W., Zhang W., Zhang H.;
RT "Draft genome sequences of 29 type strains of Enterococci.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis
CC via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate:
CC step 1/3. {ECO:0000256|ARBA:ARBA00029438}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJG18353.1}.
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DR EMBL; JXKH01000004; OJG18353.1; -; Genomic_DNA.
DR RefSeq; WP_067395919.1; NZ_JXKH01000004.1.
DR AlphaFoldDB; A0A1L8RF47; -.
DR STRING; 214095.RU97_GL001750; -.
DR UniPathway; UPA00057; UER00098.
DR Proteomes; UP000181884; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004496; F:mevalonate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.890; GHMP kinase, C-terminal domain; 1.
DR InterPro; IPR013750; GHMP_kinase_C_dom.
DR InterPro; IPR036554; GHMP_kinase_C_sf.
DR InterPro; IPR006204; GHMP_kinase_N_dom.
DR InterPro; IPR006205; Mev_gal_kin.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00549; mevalon_kin; 1.
DR PANTHER; PTHR43290; MEVALONATE KINASE; 1.
DR PANTHER; PTHR43290:SF2; MEVALONATE KINASE; 1.
DR Pfam; PF08544; GHMP_kinases_C; 1.
DR Pfam; PF00288; GHMP_kinases_N; 1.
DR PRINTS; PR00959; MEVGALKINASE.
DR SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OJG18353.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000181884};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 86..147
FT /note="GHMP kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00288"
FT DOMAIN 218..295
FT /note="GHMP kinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08544"
SQ SEQUENCE 312 AA; 32269 MW; 2830A601B2A04CA0 CRC64;
MNATGFGAAN GKIILMGEHA VVYGEPAIAL PFSAVQLSAE VTASQAWQID SVYHQGLLAD
APHHLENIKQ LVQELAAAWH LTPLTIKITS TIPPERGMGS SAATAVAVTR ALADAVGHAL
TTTELQKWVA IAEKIAHGNP SGIDAAATSG LNPIYFIKGE PLTAFPMNLS HGILVVADTG
IKGQTRGAVK DVAHLFETTK KATAQAITTL GHLAKASREA ILADDLDALG ATMDQAQTLL
KQLTVSNQSL DELVATAKVQ GALGAKLTGG GRGGCMIALA PDQQTADKIQ QALATKAAAT
WQFNLGGDTH EG
//
