ID A0A1L8TMQ0_9ENTE Unreviewed; 717 AA.
AC A0A1L8TMQ0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=RV04_GL001880 {ECO:0000313|EMBL:OJG45591.1};
OS Enterococcus hermanniensis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=249189 {ECO:0000313|EMBL:OJG45591.1, ECO:0000313|Proteomes:UP000182077};
RN [1] {ECO:0000313|EMBL:OJG45591.1, ECO:0000313|Proteomes:UP000182077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17122 {ECO:0000313|EMBL:OJG45591.1,
RC ECO:0000313|Proteomes:UP000182077};
RA Zhong Z., Sun Z., Liu W., Zhang W., Zhang H.;
RT "Draft genome sequences of 29 type strains of Enterococci.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJG45591.1}.
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DR EMBL; JXKQ01000005; OJG45591.1; -; Genomic_DNA.
DR RefSeq; WP_071857767.1; NZ_JXKQ01000005.1.
DR AlphaFoldDB; A0A1L8TMQ0; -.
DR STRING; 249189.RV04_GL001880; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000182077; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000182077}.
FT DOMAIN 34..334
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 335..619
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 55..62
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 717 AA; 82836 MW; 685151F104DE6B04 CRC64;
MSKLSDYIKD ELIENDSDKN KTINYLVKQN NGLMFSESQL SAIQFPMQTH LRIIAGAGSG
KTQTICAKAA YLILEKKIAP QKIIMCTFSR KAKLEMEARV NRYLGGNARV KVQTFHGWFN
GEYNELIRNN PTLKQWGITG SIDEDQYYQT VNQLIKKYRL YNFDKFEERT ISSRISYWRN
MGYSDAEMVQ FVAKYFDKED LLPNQRLSEI FQKFLAELSL IKQNQQFINF DDMLFNLKII
LENDAAARKT VQTKYQYIFI DEFQDINPLQ KQIVALICPP DKNRLLKHMS KLIIVGDDDQ
SIYYFRGAEP KYIQQFEEEY QQTSLKLMTN YRSEAPIVAA GNQLIKYNKH DRLEKTMTAA
KTAANHDCYS MSFPDDDVEA TWIGQKIQTL AKVAPLRDGS PDYRDTMVLY PTRGQLRSLL
KQLEKQKVPF VTPSNDDLLG IFGLPLFKNL FQQLQQMAEA SNAAQKNMAL KNIIQQYAFF
HFIKFGTSTK FSEELFSKNK FKINDLVTFL VKEKNISLAA QSLAKAFFKQ VYLFYQRREL
DLAPVAQALL STPKFKKDLS EEEADWLSKE LLAAANWAGL IEAFKQASQQ NQGMKRRLKE
YDQDKLNAVY LLSIHSSKGL GKKNVFIKGV YQDALPNHHT VKKAACNLQQ AKEQGAPPTM
LEEQRRLMYV AITRAKENLY VTFPQMINNK AVDPSPFIQE AGLVTKKYRK PIEKEEV
//
