ID A0A1L8ZBC7_BORBI Unreviewed; 168 AA.
AC A0A1L8ZBC7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=CTP synthase (glutamine hydrolyzing) {ECO:0000256|ARBA:ARBA00012291};
DE EC=6.3.4.2 {ECO:0000256|ARBA:ARBA00012291};
DE Flags: Fragment;
GN Name=pyrG {ECO:0000313|EMBL:OJH15070.1};
GN ORFNames=ER70_04860 {ECO:0000313|EMBL:OJH15070.1};
OS Borrelia bissettiae (Borreliella bissettiae).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Borreliaceae;
OC Borreliella.
OX NCBI_TaxID=64897 {ECO:0000313|EMBL:OJH15070.1, ECO:0000313|Proteomes:UP000183624};
RN [1] {ECO:0000313|EMBL:OJH15070.1, ECO:0000313|Proteomes:UP000183624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO275 {ECO:0000313|EMBL:OJH15070.1,
RC ECO:0000313|Proteomes:UP000183624};
RX PubMed=26419825; DOI=10.1099/mic.0.000192;
RA Leydet B.F.Jr., Liang F.T.;
RT "Similarities in murine infection and immune response to Borrelia bissettii
RT and Borrelia burgdorferi sensu stricto.";
RL Microbiology 161:2352-2360(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-
CC glutamate + phosphate; Xref=Rhea:RHEA:26426, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:456216; EC=6.3.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000314};
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway;
CC CTP from UDP: step 2/2. {ECO:0000256|ARBA:ARBA00005171}.
CC -!- SIMILARITY: Belongs to the CTP synthase family.
CC {ECO:0000256|ARBA:ARBA00007533}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00605}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJH15070.1}.
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DR EMBL; JNBW01000245; OJH15070.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L8ZBC7; -.
DR UniPathway; UPA00159; UER00277.
DR Proteomes; UP000183624; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003883; F:CTP synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR004468; CTP_synthase.
DR InterPro; IPR017926; GATASE.
DR PANTHER; PTHR11550; CTP SYNTHASE; 1.
DR PANTHER; PTHR11550:SF0; CTP SYNTHASE-RELATED; 1.
DR Pfam; PF00117; GATase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:OJH15070.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975}.
FT DOMAIN 4..167
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OJH15070.1"
FT NON_TER 168
FT /evidence="ECO:0000313|EMBL:OJH15070.1"
SQ SEQUENCE 168 AA; 18835 MW; C6CFC089D3202EE2 CRC64;
AELDDSYASI RESLVHVAAN LDLLIKSTII DSNDLNENRL KEFDGIIVPG GFGGKGYEGK
IMAIKYAREN NIPFLGICLG LQLAVIEFAR NVCGIFDADT EENLAKDKPL KSPVIHLLPE
QKEIKDKGAT MRLGGYPVIL KKNTIAFKLY GQDRIIERFR HRYEVNND
//
