ID A0A1L9MUK6_ASPTC Unreviewed; 2542 AA.
AC A0A1L9MUK6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=USP domain-containing protein {ECO:0000259|PROSITE:PS50235};
GN ORFNames=ASPTUDRAFT_865513 {ECO:0000313|EMBL:OJI80654.1};
OS Aspergillus tubingensis (strain CBS 134.48).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767770 {ECO:0000313|EMBL:OJI80654.1, ECO:0000313|Proteomes:UP000184304};
RN [1] {ECO:0000313|Proteomes:UP000184304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 134.48 {ECO:0000313|Proteomes:UP000184304};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
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DR EMBL; KV878207; OJI80654.1; -; Genomic_DNA.
DR STRING; 767770.A0A1L9MUK6; -.
DR VEuPathDB; FungiDB:ASPTUDRAFT_865513; -.
DR OMA; SAIQCEI; -.
DR Proteomes; UP000184304; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR021905; DUF3517.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006:SF953; C-TERMINAL HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08440)-RELATED; 1.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF12030; DUF3517; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000184304}.
FT DOMAIN 1625..1954
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2519..2542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2542 AA; 286657 MW; FE803A203748A15E CRC64;
MAAAPLESSS TPPETTSSID STRPLGHPME ESDPQSTRKR PRLDSGSGTC ESRSIPDETA
ATRFPNDIPD APATTGQDAS PSSRPASRVV IKLKSPVPDN MASEPGDSPV EHPSRDPPTQ
PAAGGIGLDA STAISLSSSP TQSPEIEVAD LEDMDQDPNT SSWKSLGEAM REPETPEVVQ
LHDQPPLVET FPRLFMGNEL RENLEEICTM IEKGKALLRW PYAGFCRADS DSYSIGSQHD
TPVFVAVKAW FDDVANNLDQ LTYEVLAEDR DFWEELPSVV DSLLRRVVEL LPDEGRGVWA
CLEEFFLDFA HLAVHVIDLD TIILTQAVDD AEAQIADPLS KPYLVSLGWI LQLGNIPFFR
TMENIHGSDV ANLVARTNDQ VADALDIIQH LSDHAVCILN LITRWSQLST SLIAIVNIVH
NLIESGNERR RYHADDALIN SSICSRTMRR AYPLIRAADE KYQFHITKKS PWVSSETSDS
MLRHIAFSYT TLCNRDSELA SQIAEDLAIE LSEDVTPEDR SSIIFYGWKF GVLKKHIMDG
RMELRVFGVE TMQAELVHIW RQHIHRNTES TIHPVVDYLV GFLRQNRIVE YIVGIDSHPQ
LISRSGNIVG FLVVTATYTD ADTDTIWETV TESPDPRTVS EVLGMLSKTF QMHTSNSPAL
LYVCSKLLDL PLARFDARMV DFCEQLLHQV REKCSDRSHR EAQDRIHVDA IPLRLCVRLI
RESAGANDFP VEHKALLQKF AAAQLKSFMD IGLSEVDKME IYEQCLKDIA EMNQFTVGSI
QALNALLPSN DSLELRKLAE EFDLTRLVIT ELAQTVDMNQ TDFTDPFSLT GFSSRVHMLA
RIIDMVPDSI TPDLGDLLWR RVFMSKSLAQ QGRRALWDML CATARYSAQA NSLVERCIQV
YLPELSPAED YLPEVLQFAK QTINYEVRFN PPSIAGENEV VAIPGMDRIW SFILTAPPGT
IETDAITFAI EVYLDHSIIN RSPRSAVEAT HIALVDRCVD QLKSAASRLK ESRDNSDTVE
DASMDAVAPD TNIKAEELRF SRSLLFLRRF LQGLRCRPQY SPPQSLPLDS PGKPIQGDAI
DIRYQTFNGG TQSKVRSLHI GDLSTAAELA ETLVRVTGFT KFSTISGGQR IDLLEKPGIT
IRDLKLGSGL LLIRRDPESR ELAMTGRRQS LTLVDSEVLK HFDDLYDLLV LEDHLAREIY
DFLVVFPPQD RVLELVKSTD KTEDEMFPMD KPFSLLYSVN ALSVSLREET LEASPNQDYV
SHSIRVLVSA LTRSEMAGGL KDSPTKLLFA THMVECLLYA LLVRPAIPGE APVVPNPTAL
VQRLFHFMEV ARLLPVSSPS ETSITKLICN SFAVLTEGSV RDLGFWEAVK EQPHFDDLLC
SLLLKEHRQP IRKGIAENIA VACSPSKLLR KSTKPIDSET QGTQDTPAPD NAIRIEILAK
IWNAFDKAFP ATLDNAAQCQ EFFEIANLVF RSVAERSPHD LSFSQYLKQW STTMLRHQTE
EFVGREPVDH LILGFARLLR ICLELAGSND TTVDTFDLAE SLFDQYLFPD LSSPSTDLIV
PQVPVMHTQT RQELYSILCQ LCRLDENNYS TIVERLEDLI PLDYTYSPAW GFDRYKMLRS
PEGYAGLKNL SNTCYLNSLL TQLFMNVGFR DFILQLDLED PDGSQKLLYE TKKLFGHMQE
TWSKSVDSQA FVDTIRTYDN EPIDVTIQMD VDEFYNLLFD RWEAQISDNE SKKRFRSFYG
GQLVQQIKSK ECPHISERLE PFSAIQCEIK DKASLEDSLQ AYVEGEIMQG DNKYSCTSCG
RHVDAVKRAC LKDVPDNLIF HLKRFDFDMV TMLRSKINDE FQFPDFIDMS PYKVEYLSDQ
TAEVKEDIFE LVGVLVHSGT AESGHYYSYI RERPTSGAGG SWVEFNDSDV SRFDQAKLAD
QCFGGHNDSG QSSAMGQVRF NKVWNAYMLF YQRASSMEAE KAIYKPTKPQ HPVGVSLPRE
LANHIVMENE IFIRVYCLMD PYHALFVRYL LSMILEERGP RSDIKAKLDK SMIFIALDTL
EQLLSRSREP LGLDAFVTLL FTVISEVPMA AYRVMQWFEN KPSATRNLVL RSPHPAVRSN
SIRLIICSLS KLQGLQKGAD DEDVEKEVWK MRYLNSFENV VRTLESMWST LHTASRSWDD
YFEFLSMLAN FGQYEAGIIL NNGFLLKCLE IVWLDHEDSK RLRRQYAFII KFMEKGRRFS
YKRLMDLLAY LIARIDLTVP PSQDDKRRTL PDGRYTLTMS EAMFIRPLGK SKELSFLTTV
LTHNSSPPAS RNIVTLFVDA EPDAGLMDPI CRTLEEGLRL APASLCAPFL EATLIFCRRG
PDEARIVSLI DFVAKGVDSI NDSGGREHIV FFTSVMGSRN DRLGLNEAWF LNHLIEMVPE
WAPPLLTFPD RGVRNMTLDV LRQILFSGEA EEAGDDWQTR QAEVAKKLVH ASINRLRKAY
VNVPGSGVDP RAVESIRTVV EHCLSTYFGD SEEDQEAILQ AQETIAAVED LIAEVPEELA
SEDWEDNSVM ASDSEMGLAG SP
//
