ID A0A1L9MUV8_ASPTC Unreviewed; 689 AA.
AC A0A1L9MUV8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Nucleolar complex-associated protein 3 {ECO:0000256|PIRNR:PIRNR028977};
GN ORFNames=ASPTUDRAFT_46049 {ECO:0000313|EMBL:OJI80836.1};
OS Aspergillus tubingensis (strain CBS 134.48).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767770 {ECO:0000313|EMBL:OJI80836.1, ECO:0000313|Proteomes:UP000184304};
RN [1] {ECO:0000313|Proteomes:UP000184304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 134.48 {ECO:0000313|Proteomes:UP000184304};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- FUNCTION: Required for synthesis of 60S ribosomal subunits and the
CC transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
CC {ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797, ECO:0000256|PIRNR:PIRNR028977}.
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DR EMBL; KV878206; OJI80836.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9MUV8; -.
DR STRING; 767770.A0A1L9MUV8; -.
DR VEuPathDB; FungiDB:ASPTUDRAFT_46049; -.
DR OMA; HYCPQVR; -.
DR Proteomes; UP000184304; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; NUCLEOLAR COMPLEX PROTEIN 3; 1.
DR PANTHER; PTHR14428:SF5; NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000184304};
KW Ribosome biogenesis {ECO:0000256|PIRNR:PIRNR028977}.
FT DOMAIN 125..217
FT /note="Nucleolar complex-associated protein 3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07540"
FT DOMAIN 486..678
FT /note="CCAAT-binding factor"
FT /evidence="ECO:0000259|Pfam:PF03914"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..112
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..472
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 78449 MW; BBC5F8DD8FC97FEE CRC64;
MAPARTTKRR RVSPPGDEER GSKSSGGAST SDFYSNAAEW DLEQDYEQRP RKLGKKDKEQ
TRLPIKTAEG LQNVAEPEPE PEAEESDSFL GTDDDEGMED ADTDEDEEEV EEEKPKIPLK
LQIIQTKEEL ARLATLINED PEENMPLFKT MAEIMERGEH VAIKKLALAA QAAVYKDVIP
GYRIRPLGDE DLSAKISKEV RKLRTFEQSL LSNYKHYVQK LVDLTKPAKK DGPQVDPGLK
SIAINCACNL LLSVAHFNFR SELLKILVNR LARKQVDADF VKCRETMEEV FIRDEDGVVS
LEAVRLLSKM MKAKEFRINE TVLDTFLHLR LLSEFSRKAS RDRIDREEEE ETPQFGKKPK
QKREFRTKRE RKVQKERKAV EKDMKEADAL VSHEERDKNQ AETLKLVFGV YFRILKLRIP
KLMGPVLEGL AKYAHLINQD FFGDLLEALK DLIGHADRAE EEEEEEETDE TNEAEPATTR
DAQREALLCT VTAFALLEGQ DASKAASTLH LDLSFFVKHL YRSLYNLSIN PDVEFNPDKS
LRLPDPNSPE ANPAYRSRKK VNFQTPMVLL LRCLQSTLIS RAHGMPPPVR LGSFSKRLMT
SSLQLPEKSA LATLSLMNQV AKHNARRISS LWHSDERKGD GVFNAYATDI EATNVFAGTI
WEGELLRQHY CPQVRDAALD VEKMIATRK
//
