ID A0A1L9MW75_ASPTC Unreviewed; 2113 AA.
AC A0A1L9MW75;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=ASPTUDRAFT_128629 {ECO:0000313|EMBL:OJI81264.1};
OS Aspergillus tubingensis (strain CBS 134.48).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767770 {ECO:0000313|EMBL:OJI81264.1, ECO:0000313|Proteomes:UP000184304};
RN [1] {ECO:0000313|Proteomes:UP000184304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 134.48 {ECO:0000313|Proteomes:UP000184304};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KV878206; OJI81264.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:ASPTUDRAFT_128629; -.
DR OMA; DHHTLED; -.
DR Proteomes; UP000184304; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17330; MFS_SLC46_TetA_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR025925; PPC89_CLD.
DR PANTHER; PTHR19336:SF9; SPINDLE POLE BODY PROTEIN PPC89; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14197; Cep57_CLD_2; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000184304};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 51..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1671..1689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1730..1753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1783..1805
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1895..1920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1947..1969
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1981..1999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2080..2099
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1598..2103
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 12..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1420..1452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1491..1589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1860..1885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..669
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1039
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1505..1537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1551..1576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2113 AA; 234864 MW; EDF5C1FE2011AA09 CRC64;
MHIPVNFRQF DIRQDGPGNI INNPNTNTNN TDNSPDKNHA SDNDNSSRNN IIIICVACII
FAVASALMTY FVLRTLRRMN CRPKYLPGKF LKDKWNRWNV GVSYGQVPGA NNPNANTRDT
PAEGGSEMRT TTPAANNTSN VRRDTSVRSV ITLPAYSPSP KPTEQVIARE GERAGMDMVV
EFPETAEEEE SRREELMESL YQIRLQRREE IADREWRRQE RREARARGDY IRLEELRQES
RARARSSASA NGSGSNLSAA LAESRNRGRD RRISSVSYAE LGHVRHDGSR IRATSPDSDR
RPLLTDASAP ERSSGSILTG VHSRGESYSS YQSGVSNVSD AETLTQVQSH AASAHSADRP
SITVDEGDVG ELNIPPPEYE VLEWGEAPPY TSPIAERGEH APQLRDLTPL PTIHIDVASP
ISNTPTTPTN PLREEEPEEQ QTAEPTTEQP ATTTQPITEE RVEEHPASES AETHLLRDDT
HTGNMSREAT TNSFASFGSD FDPEHEALAS TKELGHGSPR LPSMHTNARK RHEYEEEEPD
YAFNTSTFEQ YLPDFSPVGT SEEEEEADND DSISIEAGRG PTKPPRRLDD SRNSYMSIEN
SVRSSSPAVR LDYPTSNTPQ KSALRNPARR AVSDSLRKDA QIRRASLAHK ENVDPNTAKS
NRKERRTLSD MHAKVRDTYE GSLIEDERPP VMANSTRPTR FGNPNLSHQI ADAVEKASQE
AYARELRRGK SSNSSRNMAN NAGDTATQQS FLLPDLPNLS ELVSGVYEDG TPVYARQNRA
RTTRFVSPPH DATDVSLTRE HMPLDAVPIP EDEKALFVSL RLLQDKVAEL ERSKSDAERR
MDDMKRENEA LRANKRSKDK HGRSRPYESD EDDYRRDQLA NENQKLDAAN LALQNKLDII
ERKAQIQEST LKRLNRERDM AVSQLGVAYL ESQDLKSENE SLRQENADLK SQISKILSAG
SRAREDTVES EQSSMTDASD EDSQIDTQHS KHTSRSTREV TGKSSRSKSR RQEDSRAKIS
TQVDKEISRL EKERAEEALF SIDVPQTREK SKSRSGKSKS RSESSDVSTR KQSNTGKQRV
KRVVVEEVEE TEPVESSGEV TGNTKKSNAT EQDLTLLSFV DEREIAQLRK TLEEERLARK
RRQSSTSKEQ TANETGNTTR QSLAKSTIPR KSSLKESKGL PSRPASAMGD LTANSKASMT
EGESNLSVPV ERPRRHSDNS GAAASQRRRR RMAEEMTSAF ILPDITFNPA HLVENNLSKL
PEPAQRALDS ATKHNGKNCT VCKQSIPGAS CEHTAEAVKI PKPVPVSERM PEPSVYNEEP
TMRPAQSPEL ALATVLKALE DELAHLKMQL VAYQGSYNKL DASLSKRQRK SVGEKIEKLL
KDIDMKADQI YALYDVLEGQ KQNGREMTEQ EMEVTLQSIG IDTAGRTADV TATTDKSSRK
EPDSEDDDEL PWEGFESTLE MTGRTDLYMT STQPPEIRNS HTDNHVDTTT AISAPEADAS
RLRKNPDTQF LSPAMSVDSS IDGDKDSVNT AIHDGSSAQT RILAPAPMPE SSQSRRLSVD
DHNNTNLIAN EDAPNPNEEN NDADEKPVTW SSLPKKSQLA ILTIARLSEP LTQTSLQAYM
FYQLKSFDPS LPDSTISGQA GILQGSFTAA QFLTAVWWGR LADAEWMGRK RVLLIGSLGT
CISCLGFGFS RSFVAAAVFR TLGGVLNSNV GVMRTMIAEI IEEKKYQSRA FLLLPMCFNI
GVIIGPVLGG ALADPVKNYP QFFGPGTFLG GANGVEWMRK WPFLLPNLLS AVFIFCSLLA
VFFGLDETHE TARHRSDWGR QLGHHISRAL RRTRRKDSKY YQRLTEHPDD ESLYIDNTSH
HRRSISISSR SSRPKPSSTT TSSRPSFRQI YTRNVLLTLL AQFLLAFHTS AFNAITFTFL
PTPRAPPSTR TGWFHFSGGL GLPSSRVGLA TAIIGIIGLP LQIFIYPWVQ GYLGTLRSFR
TFLPFSSLAY ALMPFLLLLP RAAYVVWPAF TVVIALQVVS RTFALPAAVI LVNNSVSDAK
VLGTINGVSQ SISSAARTLG PFLGGWGLGE GLKGNFVGGV WWGLAVEAMV GWVVLWFIWE
GRGIERKKTR SKK
//
