ID A0A1L9MZF6_ASPTC Unreviewed; 919 AA.
AC A0A1L9MZF6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Cyclic nucleotide-binding domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPTUDRAFT_57922 {ECO:0000313|EMBL:OJI82202.1};
OS Aspergillus tubingensis (strain CBS 134.48).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767770 {ECO:0000313|EMBL:OJI82202.1, ECO:0000313|Proteomes:UP000184304};
RN [1] {ECO:0000313|Proteomes:UP000184304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 134.48 {ECO:0000313|Proteomes:UP000184304};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KV878205; OJI82202.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9MZF6; -.
DR STRING; 767770.A0A1L9MZF6; -.
DR VEuPathDB; FungiDB:ASPTUDRAFT_57922; -.
DR OMA; RMKSVWD; -.
DR Proteomes; UP000184304; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd09917; F-box_SF; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF16643; cNMPbd_u2; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00367; LRR_CC; 9.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Reference proteome {ECO:0000313|Proteomes:UP000184304};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 63..180
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 265..399
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 536..583
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 224..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 101855 MW; 4E441868A042C0BE CRC64;
MRRHGRASGG TKAVHPISDT ASLLHSFDSI TNPNRPVRPS PLTSSNIQAL PLDLVDRLRS
FPLFQSTPES FLVDVGQHLR PQLHAPNDYI LTEGDEAKAI YWLVRGAVSV TSRDGESIYA
ELEPGAFFGE IGVLMDRPRT ATIIARTRCL LVVLTKEDFR KILPRFPDVE RAIRDEAQER
LMILEKKKKE TSVPSVDLVS PIRRGSKRLR DTYSGDLNLA DQDGRSLKSV NKKRKSPSPG
LADGSSSALA NGLVNVRLLL KELPLFSGLP PDILHFLGLN AQPRSYPPFT DIIKQDSQGR
EIYFIVRGEV EVLSEKTPNH HAQSLPNKIE HPSFEVKARL KQGQYFGEVV SLSLAPRRTA
TVRSISAVEC LMISGEVLVE FWERCPPKVR EQVESTAKER LQAASDGDVV MSEAGADEQP
LSVDDNFKMR AGRRQSMPLL TLTETELDST PTANGLDEPS VLRPSDPDPF LSVGLDKVRL
RSRRSSVAPL TPEEVSGEQQ RSSPSSEPRS TSSSFLTLPG AGEFSTPSET VREPRRDNHG
YLPDQVLLVI FQHLELHDLL RLRAVSMHWS EILSKSTELL HHLDLSTYNR CVTDDVLVKI
ICPFVGSRPR YVDISNCFHI TDEGFSKLVA TCGSNVVTWK MKSVWDVTAS SILDMASKAN
NLQEVDLSNC RKVGDTLLAR IVGWVSPGQH KPHDESKSGK ASMKPTRQTA AGTVYGCPEL
KKLTLSYCKH VTDRSMHHIA SHAASRIEEM DLTRCTTITD QGFQFWGNAR FTNLRRLCLA
DCTYLTDNAI VHLTNAAKQL RELDLSFCCA LSDTATEVLA LQCSQLTYLN MSFCGSAISD
PSLRCIGLHL LNLKRLSVRG CVRVTGAGVE AVADGCNQLT SFDVSQCKNL LPWIEGDGPR
KYGKKISFET VAQNGRVFR
//
