ID A0A1L9N4A6_ASPTC Unreviewed; 1061 AA.
AC A0A1L9N4A6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 08-NOV-2023, entry version 18.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=ASPTUDRAFT_30083 {ECO:0000313|EMBL:OJI84110.1};
OS Aspergillus tubingensis (strain CBS 134.48).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767770 {ECO:0000313|EMBL:OJI84110.1, ECO:0000313|Proteomes:UP000184304};
RN [1] {ECO:0000313|Proteomes:UP000184304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 134.48 {ECO:0000313|Proteomes:UP000184304};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; KV878203; OJI84110.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9N4A6; -.
DR STRING; 767770.A0A1L9N4A6; -.
DR VEuPathDB; FungiDB:ASPTUDRAFT_30083; -.
DR OMA; FSFMPEF; -.
DR Proteomes; UP000184304; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000184304};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 40..297
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 545..994
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1061 AA; 117061 MW; 830EA5441DB20221 CRC64;
MSALQTFLLV VDHDKQEAKQ IAERIAQDVE TKKITLIEVV QSLGEYINDE DPILRGKAVS
YLTAVIRALP PKFLSRQQIQ VLTTFFCERI EDGGAVAGLE TLQKLDRFNK ALAEEVARAV
FERFEELQSR SQSQRFQVYQ LLNELMINHR AALHDMGDES LVGIVNLMTG EKDPRNLMLV
FSILKVVMVE WDVSNHAEAL FDSVYNYFPI TFRPPPNDPY GITAQDLKDR LQDCISANSL
FAPHAVPSLL DKLDSTSPNV KKDALNALIA CVKLYDPNTV SKYSITIWET LKFEILNAQE
EFLSELSLQV LSSIAQRLSE GVTQVSDQLP LAQFLRPITK ECSEQLQEPQ QKQAKPAQQI
LSSTSAASAA SFTLIVQTVV APLLTIYQEA DGIAKQRALL DTLTVLFDSA IQVYGAWTSR
DSEPSLSNPL LEFKDQFSDI FGQALMGVIK EEVSFRTSAL KGFLRLSTLR NYFQDNEVGL
FVQYLDEILL KEESVGRDDL KKEAIAALTE ISKYKPRLIL DITFPAFVAT LPDSDDGSNP
GYITTLETLA QISVERDIFD TLVRRLLSKL SILLQKEDPG SVDYPRAILL TILYVMNQRK
LEETPNLDLY YDKIVVSLCR SAATAALGKA PNNILTDATV LDVLGRLCNV IIRSLPQSKH
DEVVSNIYTL FASANGFQQV PFTPSPTDSH RRTMILSTYL LASLPQDTKN LPPCTPPVMS
DLLTDIATRC TAETETATQL AFLRHLALYI NKHLNKENLD LATSLFDTLL PPTTQDPQLT
TPTIKTLFWL SKALILRLSP KTTQILTTLL NLLSSSSETT STTAARGFAI LLKDDEVLSP
TNHANIRLLS KQRVFTTLTP LISARIREVN VAGNTTTTTA PTSPHIKPAH LTALSGILST
IPPTLVMPEL PTLLPLLLQS LDLQSADTQP VRAATLETLA VIIRDNGVTV IEECGHVQSL
VTRLLKTAEH APATGAVNGP KLRVDALKCL FLLAQTPGSG AADAPKVAKA GKLSPLLPVK
SQVLRALRTV LDDPKRDVRK AAVDARGAWL RGVDDAAEQD D
//
