ID A0A1L9N9X4_ASPTC Unreviewed; 1053 AA.
AC A0A1L9N9X4;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=phosphoserine transaminase {ECO:0000256|ARBA:ARBA00013030};
DE EC=2.6.1.52 {ECO:0000256|ARBA:ARBA00013030};
GN ORFNames=ASPTUDRAFT_53329 {ECO:0000313|EMBL:OJI86029.1};
OS Aspergillus tubingensis (strain CBS 134.48).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767770 {ECO:0000313|EMBL:OJI86029.1, ECO:0000313|Proteomes:UP000184304};
RN [1] {ECO:0000313|Proteomes:UP000184304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 134.48 {ECO:0000313|Proteomes:UP000184304};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate +
CC L-glutamate; Xref=Rhea:RHEA:14329, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:18110, ChEBI:CHEBI:29985, ChEBI:CHEBI:57524; EC=2.6.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001871};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from
CC 3-phospho-D-glycerate: step 2/3. {ECO:0000256|ARBA:ARBA00005099}.
CC -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC aminotransferase family. SerC subfamily.
CC {ECO:0000256|ARBA:ARBA00006904}.
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DR EMBL; KV878187; OJI86029.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9N9X4; -.
DR STRING; 767770.A0A1L9N9X4; -.
DR VEuPathDB; FungiDB:ASPTUDRAFT_53329; -.
DR OMA; ANKETDF; -.
DR UniPathway; UPA00135; UER00197.
DR Proteomes; UP000184304; Unassembled WGS sequence.
DR GO; GO:0004648; F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity; IEA:InterPro.
DR GO; GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR HAMAP; MF_00160; SerC_aminotrans_5; 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR027796; OTT_1508_deam-like.
DR InterPro; IPR022278; Pser_aminoTfrase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR43247; PHOSPHOSERINE AMINOTRANSFERASE; 1.
DR PANTHER; PTHR43247:SF1; PHOSPHOSERINE AMINOTRANSFERASE; 1.
DR Pfam; PF00266; Aminotran_5; 2.
DR Pfam; PF14441; OTT_1508_deam; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aminotransferase {ECO:0000256|ARBA:ARBA00022576};
KW Reference proteome {ECO:0000313|Proteomes:UP000184304};
KW Serine biosynthesis {ECO:0000256|ARBA:ARBA00023299};
KW Transferase {ECO:0000256|ARBA:ARBA00022576}.
FT DOMAIN 9..122
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
FT DOMAIN 167..414
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
FT REGION 474..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 119107 MW; DCA8AA23099AF7C4 CRC64;
MKREDITYLG AGPASLPTDV LATAAQALQN YQDTGLGVAE HSHRSEIATN ILNGAKADLA
NFLDIPDTYE ILFLQGGGSG QFDATVYNLV SIWAEKQRQQ IIKEKAGISE DEVISELRKK
VESELKLDYL VTGSWSLKAS QEAVRLLGSE YVNIVSDSRT VNDGKFGKIA DESTWKLSRK
AALVYKCENE TVDGVEFPSF PKVLEPKGTD EDPIVVGDFS STILSRRIPV QNYSIIFFGA
QKNLGVAGIT GVIIKKDLLP PVSSPCSPAI LRKLGLPVAP TILDYSVAAK NNSLYNTLPI
FDVYIAGQVL KKLLASFPDK VDGQQAVADR KAKLIYETLD AYPEVYKVVP AKEVRSRMNA
CFRVIKGGNV DDAEKAFLKG AVERGITGLK GHRSVGGIRA SNYNAIPESG IEKLAAYLKE
FYAGLVVHNR MSHVKKLHLL RPTAGIKTDV WNLPNEIESQ ITTLAAVLQV QQQQRTPIAR
EEEEGEEETD DEETSNEQLH NHELGSSAVV APLASENTKN LRRCFLDQLA ELLCYKKDAH
YVTCTYLREE VDEVTILASR NAAWEDKDIR LLESLAGTLE QLAVRDPFNL DFKPDLEREF
SEYYTPRLKY HVKQLVNFLE AVKGETGLVD FLRNFFSRRI SSQRIWANID FRYRIEVLPK
ANKIVRELGY ILRPIVAADT FDKAAREISN FQRVKIELLP GYKAESVTPS LSLVSRTPQY
LGISKKTCFM CGHFLQSLSQ FQARNNHGKV YSQWRLPKSL IMPPKYCETL DNAARNLRDV
MQCEFAPQHM RIWSPFSRHV PDPKLQARES EWLSYRSPRE IAVRSNNDVA KAFGILYFTS
AADQHRLFEL YCSLVNDWGV GEEELREAWQ QNKLKEFILF RSSQIPSTWI HNESHWISQQ
DGFAANKETD FNIVLESQKH VLKPEDQQVP YQLWKPREKL EAFVFLCQIR NGYIPQADEY
NWISLGFCTA RDGSETQKVA ELYKELLDTC VFEEFWKAMV ESKMVDLFRK YGLGDAIAEL
RNFETLLSAV GTTHQSCYRG LWILQLSNTT GAE
//
