ID A0A1L9NLR3_ASPTC Unreviewed; 4344 AA.
AC A0A1L9NLR3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=ASPTUDRAFT_111685 {ECO:0000313|EMBL:OJI90177.1};
OS Aspergillus tubingensis (strain CBS 134.48).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=767770 {ECO:0000313|EMBL:OJI90177.1, ECO:0000313|Proteomes:UP000184304};
RN [1] {ECO:0000313|Proteomes:UP000184304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 134.48 {ECO:0000313|Proteomes:UP000184304};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; KV878176; OJI90177.1; -; Genomic_DNA.
DR STRING; 767770.A0A1L9NLR3; -.
DR VEuPathDB; FungiDB:ASPTUDRAFT_111685; -.
DR OMA; NERQMTR; -.
DR Proteomes; UP000184304; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000184304}.
FT DOMAIN 1933..2071
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2225..2546
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2589..2739
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2931..3097
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1633..1660
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3193..3244
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3419..3460
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4344 AA; 492560 MW; 27F83F6471791832 CRC64;
MEVANAEVSN GVPAPAQTPL VDSNAVIEYL SEVLRVTLGA LRSELESTGS LLSPARYNET
VQRCTRFASE SQVAIYVQKD VVASEEANGT ETSEDLSSKY VYNLSAEISS SSTTVATVVF
IKRPTAIDPS LPIPSQIQVV NFPGPASLSN AQSQQGASQS PYEILHLMVH HGLNAYFEAN
TRSQEAAGGA KPRTDTEAKT GVSSTKKKFA ELELGLRHLL QNVEIPALNL PLHEVVQAAL
VDAEKRGVKP SVELIDSAIL ENSTFVNSIQ NTVNAWIRSI QTITKMSRDA DSDSAAQEIN
FWLSMETALE GIENQLRGDG VQLTMDILRH AKRYQATLSF VADTGLREAT DLVQKYNQLM
RDFPLDELLS ATTLQKVQES LNLIFNHLNK KLKICPYPIK RALALVEAIS GDLDNQIHSL
LHGRTILHLD YREFRSLMKT AGAIWRTWDE NLKEFTNVAR ESTRRRNEKF IPIKIAARHE
KTQERLKYIN TFRVNHEQLQ RTIVNVLGPK TSTAGDTAAG AGSDGAVIVE EIGDVDAVEE
VAQAYAALRN VDVLDVSPEG TQQWIKEEIA YNERTSRVEN SIIARLRDRL ATAKNANEMF
RVFSKFNALL VRPKIRGAIG EYQTQLIENV KQDISSLHER FKQQYGHSEA HAMAQLRDLP
PVSGAIVWAR QIEHQLDGYM GKVANVLGED WALHSEGQKL LAESNLFRKK LDTRPVFESW
LHDVQRRHIT ISGRLFNIIR NRAAGNTFEL TVNFDAQIIA LFKEVRNLIW LNFQVPHAVS
NISKEAKRVY PYAISLMESV RTLLQTNRSI AAMTEVAILL NGYVNDTQSM IIKGVPLRWE
SFVHSYELHV KQSALANGAI DAAIPTRGES KHVQFVREFA GSASVLQSKT AVLASINESI
QKATHELKTC PYEAAAFRQR LDAIQVAVDK LNLENYVNLG YWVANLNQKI EGILRERLHR
AIREWINSFQ EATYSSQSLQ TSSGVQTGEG ETLSYNIEFP ELTHEISMRN QFLHLDPPLQ
YARASWFAHF DNWLGVICNL EKIKSSRYQI SIDVQKVQLS EACFATLPQH CTNELGQVYN
AVESRLSEVS AYVDKWLQFQ SLWDLQSEQV YDILGDDLSQ WLQLLQEIRK SRATFDTSEV
SKSFGNIKID YEQVQTRVNA KYDQWQHEIL LRFGSKLGGR MREVHSEIAA ARRDLEGQTL
EAASTAHAVS FITIVQQCKR KAKVWEPEVD LFRQGQATLA RQRYQFPSDW LHVENVDGEW
AALNELLARK SKIVQDQTEG LRAKISAEDK VISDKITEVI SQWNEEKPVS GTIPPEEASR
TLSMFQSRLE SLQSEYEMVS KAKEALDLPA GVESSLPAIL EEVQDFMSVW AALSTIWKSL
NDLRDMLWTS VQPRKLRQSI DGLIKMTKEM PSRMRQYAAF EHIQNVLRQL LKVNPLLSDM
KSEAVRERHW QKIYKALKPG KRFSLVSLTL GDVWDLQLTA SEVIIRDIIA QAQGEMALEE
FLKSVRETWQ NYSLDLINYQ NKCRLIRGFD DLFAKCSENL NSLQAMKHSP YYKEFEEEAT
SWEDKLNRVH VLFDVWIDVQ RQWVYLEGVF TGNADIKHLL PLESSRFQNI NSEFFAVMKK
VYKSPFVLDV LAINGVQKSL ERLAELLNKI QKALGEYLER ERVSFPRFYF VGDEDLLEII
GNSNDIVRVA KHFKKMFAGL SGVLMDDDNN IVGFTSKEGE EVRLKKEVNL VKTPRINDWL
TAIETNMKLT LAELLAEAVE QFEPLYNASE VDQTAFNDFL ANYPAQIVVL ASQVVWTRAV
QRSLENGGST LQSLFDAQVR ILELLAATVL GELDAISRKK CEHMITEFVH QRDVISKLVT
ANATTPMHYL WLLQMRYVYQ PEGDFLQRLY VHMANAKLNY GFEYLGVPER LVRTPLTDRC
FLTLTQALCQ RLGGSPYGPA GTGKTESVKA LGLQLGRFTL VFCCDDTFDF QAMGRIFLGI
CQVGAWGCFD EFNRLEERIL SAVSQQIQNI QIGLKNGETD EKAQIELVGR RLSVNPNTGI
FITMNPGYAG RSNLPDNLKK LFRSVAMSKP DKELITEVML FSQGFKQAKH LSKQTVPFFD
HCSTQLSKQA HYDFGLRALK SVLVSSGGLK RTRIASSEED LGPDEVIEPQ IIVQSLRETI
APKLVREDVD RMLEIQKQDF AGVEYVPANY EKLTAAIRDI AKEQHFVDSE MWITKALQLY
QIQSIHHGVM MVGKSGAGKS AAWKILLQAL QRTEGVESVS HIIDSKVMSK EALYGSLDAT
TREWTDGLFT GILRKIVDNL RGEDSKRHWI VFDGDVDPEW VENLNSVLDD NKLLTLPNGE
RLNLPPNVRI MFEVETLKYA TLATVSRCGM VWFNDDTVTP SMMISNYVES LRTRTFEDLD
DDSAPSGQAA IKTQDAQDML ATILKHLLQT EDLVLQALEE AKKYNHIMEY TFIRALNTLF
SLLNKACRNV LEYNIQHVDF PLDYDQIEAY ISKKLLLALV WSFTGDCPLA DRQSFGQFVS
ALTTIDLPPD GAASIIDFDI TLPKCEWASW QSQVPTIEIN THSITQTDVV IPTVDTVRHE
DVLYSWLAEH KPLLLCGPPG SGKTMTLFAA LRKLPNMEVV GLNFSSATTP DLLIKTFEQY
CEYKKTLNGV VMSPNQIGRW LVIFCDEINL PAPDRYGTQR AISFLRQLVE QNGFWRTSDK
TWVTLDRIQF VGACNPPTDA GRTAMAERFL RHAPLVMVDY PGEVSLNQIY GTFNSAILKI
LPLLRGYSES LTKAMVQFYL ESQARFTPKI QPHYVYSPRE LTRWVRGVYE AIKPLETLSV
EGLVRIWAHE ALRLFQDRLV TEDERNWTAD AVRRIALDNF PTIDDQEALK GPILFSNWLS
KNYVPVEQER LRDFVKARLK TFCDEEVDVP LVLFNDVLEH ALRIDRVFRQ PQGHLILIGV
SGSGKTTLSR FVAWMNGLKV FQIKVHGKYS SEDFDDDLRT VLRRAGCKGE KICFIMDESN
VLDSGFLERM NTLLANAEVP GLFEGDEFSS LMTACKEGAQ RQGLLLDTQE ELYKWFTSQI
VKNLHVVFTM NPPEEGLSSK AATSPALFNR CVLNWMGDWS DQALFQVGSE LTQSVDLDKP
NFIAPDSIPV AYRELSLPAS HRDTVINAMV YIHYSLQRFN QRLQKQQGRT TFLTPRHYLD
FVAQYVKLFN EKREDLEEQQ RHLNVGLEKL RDTVDKVSDL RASLAQKKTQ LEKKDTEANE
KLQKMVADQR EAEQRKAVSL EVQAALEKQE AQVALRREVV LSDLAKAEPA VIEAQKSVSN
IKRQHLTEVR SMGNPPASVR LALEAVCTLL GHKVDSWKTI QGIIRRDDFI ASIVNYDNER
QMTRNHRIKM RNEFLSKEDF TYERVNRASK ACGPLVQWVE AQVNYSEILD RVGPLREEVD
QLEEQALQTK AEAQTIENTI KGLEDSIATY KAEYAALISE TQAIKTEMSR VQFKVDRSVR
LLDSLSSERT RWEEGSRSFE TQISTLVGDV LIAAAFLAYA GFYDQQFRKA MIDEWVTHLT
QAGINFKPHN PITEYLSNAD ERLAWQDHSL PVDDLCTENA IVLKRYNRYP LIIDPSGRVT
EFLEKESTDR KLTVTSFLDD SFVKQLESAL RFGNPILIQD AEHLDPILNH VLNKEYQKTG
GRVLIQLGKQ EIDFSPSFKL FLSTRDPSAT FPPDVCSRTT FVNFTVTQSS LQTQSLNEVL
KFERPDVDAR RTDLVKLQGE FKIHLRQLEK RLLQALNESR GNILDDDNVI ETLETLKKEA
AEISKKMVET EGVMTEVENI TLNYSIIARS CSAVFAVLEQ LHHVNHFYQF SLQFFVDIFN
SVLYQNKRLA QEKDHAARVQ IILRDLFVTT YQRTSLGLIQ KDRITFAMLL AQAAPYPMDK
RIIDMILDES MESVDLSTSP ELKEQVLNKI ANMSLYKSIF PTITSEQWEQ FFSDELAENS
IPVVLEETTE NIDRLLRSLL LVKLCRMDRF VPTAERFIEA VFGRELFEGS TDLKDIVSQV
TATTPIALSS SPGFDASYKV DALVERMNAT CANIAMGSNE GLESADKAIS NAAAAGNWVQ
VKNVHLAPSW LQSLEKRLES LKPHKDFRLF LSMESSPKIP VNLLRASRVL MYEQPAGVRA
NMKDSLSSLS TRASKAPVEK ARVYLLLCFL HAVVQERLRY APSLGWKGFW EFNDSDYECS
AHIIDYWVDT IAQGRSNVAP QKLPWDMIRT LVTETYGGKV DDFADFKQLE SLVTNLLTPA
AFEDEHKIVS GVENDDCLTL PGGTSIRDFV EWVNKLPERE PPTYLGLPAN AEKLLLVGHG
NKMISDLSRV TTLLDEGEQL MIEA
//
