ID A0A1L9NWZ8_9RHOB Unreviewed; 1043 AA.
AC A0A1L9NWZ8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA translocase FtsK {ECO:0000256|ARBA:ARBA00020887};
GN Name=ftsK {ECO:0000313|EMBL:OJI93810.1};
GN ORFNames=PFRI_19570 {ECO:0000313|EMBL:OJI93810.1};
OS Planktotalea frisia.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Planktotalea.
OX NCBI_TaxID=696762 {ECO:0000313|EMBL:OJI93810.1, ECO:0000313|Proteomes:UP000184514};
RN [1] {ECO:0000313|EMBL:OJI93810.1, ECO:0000313|Proteomes:UP000184514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH6-1 {ECO:0000313|EMBL:OJI93810.1,
RC ECO:0000313|Proteomes:UP000184514};
RA Poehlein A., Bakenhus I., Voget S., Brinkhoff T., Simon M.;
RT "Genome sequence of Planktotalea frisia SH6-1.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Translocation stops specifically at Xer-dif sites, where FtsK
CC interacts with the Xer recombinase, allowing activation of chromosome
CC unlinking by recombination. FtsK orienting polar sequences (KOPS) guide
CC the direction of DNA translocation. FtsK can remove proteins from DNA
CC as it translocates, but translocation stops specifically at XerCD-dif
CC site, thereby preventing removal of XerC and XerD from dif.
CC {ECO:0000256|ARBA:ARBA00024784}.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OJI93810.1}.
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DR EMBL; MLCB01000130; OJI93810.1; -; Genomic_DNA.
DR RefSeq; WP_072630523.1; NZ_QKZM01000021.1.
DR AlphaFoldDB; A0A1L9NWZ8; -.
DR STRING; 696762.PFRI_19570; -.
DR Proteomes; UP000184514; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000184514};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 678..897
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT BINDING 695..702
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 1043 AA; 112506 MW; F3AA10D07B376358 CRC64;
MAYQARGRDP LLDSNMQAMI EKRGKEMIGA ALIIFGILAA MVVGSYTPTD PSWLSATDAP
VQNWLGQLGA SIAAPLFMIV GKAAWVIPVV SLGWGVRFVL HFGAERALGR IIFLPIAVVV
CAVYMSSLVP GAGWTHTFGL GGLFGDTVLG AFLTFLPFSA TVGLKLIAFF LAIATVAMLA
FVLGATRYEL KESARFLAIG VVVTYMMAMR LIGKGAKGAV GAASTLQARQ TEKRDALRAE
DEARAARRLA DEPRMSHIAS EPVIEPVYEE PEPAPEKEKL GLLARMPSLI KRADPMPEPE
LVEQQALENY AEMPTDDRIK SKISNVIKSR ARNHMVTQPP VSSHPAKSRS RGPIPLVVDT
TLPNMRVEPP LSASLIAQPP LAEMAEPSAL AFTSARMEAV AEPAEPVEAP IMQEPVAQAP
AFLSASYQTQ PPLEQPVPQE PMAYVAPAAS MPEPTLAPVT SFDAMPTEYL PTPELADVPS
FESAPLVTEE EIATFAPLPD PVPAPAPKSV VQHAQRKPMQ PSTRAKAEAQ PTLKFADSKE
AFELPPLNLL ESPSTVQRHH LSDEALEANA RMLEAVLDDY GVKGEIVSVR PGPVVTMYEL
EPAPGLKASR VIGLSDDIAR SMSALSARVS TVPGRSVIGI ELPNENREKV VLREILSSRD
FGDGQQKLPL ALGKDIGGDP IVANLAKMPH LLIAGTTGSG KSVAINTMIL SLLYKLTPEE
CRLIMIDPKM LELSVYDGIP HLLSPVVTDP KKAVVALKWT VGEMEERYRK MSKMGVRNID
GYNSRVADAL GKNEMFSRTV QTGFDDETGE PIFETEETQP EKMPYIVVVV DEMADLMMVA
GKEIEACIQR LAQMARASGI HLIMATQRPS VDVITGTIKA NFPTRISFQV TSKIDSRTIL
GEMGAEQLLG MGDMLYMAGG AKITRCHGPF VSDEEVEEIV NHLKGYGPPN YMSGVVEGPS
EDAASSIDTV LGLGGNTDGE DALYDTAVAI VVKDRKCSTS YIQRKLAIGY NKAARLVEQM
EDEGLVSPAN HVGKREILVP EAQ
//
