ID A0A1L9P3B7_ASPVE Unreviewed; 1133 AA.
AC A0A1L9P3B7;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE AltName: Full=Mitochondrial DNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00031966};
GN ORFNames=ASPVEDRAFT_77775 {ECO:0000313|EMBL:OJI96002.1};
OS Aspergillus versicolor CBS 583.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=1036611 {ECO:0000313|EMBL:OJI96002.1, ECO:0000313|Proteomes:UP000184073};
RN [1] {ECO:0000313|Proteomes:UP000184073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 583.65 {ECO:0000313|Proteomes:UP000184073};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV878125; OJI96002.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9P3B7; -.
DR STRING; 1036611.A0A1L9P3B7; -.
DR VEuPathDB; FungiDB:ASPVEDRAFT_77775; -.
DR OrthoDB; 5403095at2759; -.
DR Proteomes; UP000184073; Unassembled WGS sequence.
DR GO; GO:0005760; C:gamma DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006264; P:mitochondrial DNA replication; IEA:InterPro.
DR CDD; cd08641; DNA_pol_gammaA; 1.
DR Gene3D; 3.30.420.390; -; 2.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041336; DNApol_Exo.
DR InterPro; IPR047580; POLG_palm_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10267; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10267:SF0; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF18136; DNApol_Exo; 1.
DR PRINTS; PR00867; DNAPOLG.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000184073};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 694..924
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 28..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1105..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 129030 MW; A5DC48582C0B4587 CRC64;
MLRSHYPPYS RGLTRFYAQR LRVRPLVQPH ASPLSIRHSS SQDGRNETQQ TQLKVPAAAR
FNEIGVQQLS DHVYSQIFFN KSKPPDPNLV ALSKDHLARH DLLGKAQEHA DPVAFDLPAL
QGQTLDEHFF KLGMDSSEPY LTHSKQYALV NSPVLPRKWI KRSGWTKYNK DGTWEAVEAP
NESMLTFDTE VMYKEHPFAV MACAVSPSAW YAWISPWLLG ESENEIQLVP LGDPTQPRII
VGHNIGYDRA RVFEEYDLKQ TRNFFLDTMS LHVAVNGMCS QQRPTWMRHK KNRDLKEKIA
SDNDSVELAA LIENKMLREE EEELWVGRSS VNSLRDVAKF HCDVTIDKSQ RDYFGELDKP
QILSKLDELL DYCAADVAIT HRVYKRVFPN FLEVCPHPVS FGALRHLSSV ILPVNQSWEE
YLHKAESTYH QRLDDVQRRL VELCDEALSV KDDPEKYNND PWLRQLDWSG QEIKMVKGKK
KGDPPRPAAR QKKPGMPQWY KDLFTSNTSD INLTVRTRIA PVLLKLSWDS HPLIWSDKHG
WAFKVPREKA HLYENQPVVA CDMSEEKNAE LQNDRRHIYF KLPHKDGPQA RCVSPLAKGY
LQYFERGTLS SQYTLAKEAL EMNASCSYWI SARDRIMGQL VVYENDVRSL TPKKKENEKL
GFILPQIIPM GTITRRAVEN TWLTASNAKE NRVGSELKAM IKAPPDYAFV GADVDSQELW
IASLIGDAQF QLHGGNAIGF MTLEGSKAAG TDMHSRTAKI LGISRNDAKV FNYGRIYGAG
VKFAATLLRQ FNPSMTERQT QDVATKLYRE TKGAKTTRRL LSDNPFWRGG TESFVFNKLE
EFADQERPRT PVLGAGITEA LMRRFINRGS FMTSRINWAI QSSGVDYLHL LIISMDYLIR
RFNIQARLAI TVHDEIRYLV KEEDKYRSAL ALQVANVWTR AMFSQQVGIN DLPQSCAYFS
QIDIDHVLRK EVDMDCVTPS HPHKIPHGES LDILELLNKN DQARLDPSIT PVSPPSPENF
SYTPRETVMS ALQTSNNPAL IKAQITKGDK ELREIIKEVT QANTPTKQTT TRSNTRTKSA
SGSTATAEPQ KAILMDIGSG LYGGDFRDFP QGSRPPQVNF GRQTWKPRPT ARA
//
