ID A0A1L9P8G8_ASPVE Unreviewed; 1379 AA.
AC A0A1L9P8G8;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Protein CFT1 {ECO:0000256|ARBA:ARBA00039443};
DE AltName: Full=Cleavage factor two protein 1 {ECO:0000256|ARBA:ARBA00041264};
DE AltName: Full=Protein cft1 {ECO:0000256|ARBA:ARBA00039187};
GN ORFNames=ASPVEDRAFT_126107 {ECO:0000313|EMBL:OJI97734.1};
OS Aspergillus versicolor CBS 583.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=1036611 {ECO:0000313|EMBL:OJI97734.1, ECO:0000313|Proteomes:UP000184073};
RN [1] {ECO:0000313|Proteomes:UP000184073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 583.65 {ECO:0000313|Proteomes:UP000184073};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- FUNCTION: RNA-binding component of the cleavage and polyadenylation
CC factor (CPF) complex, which plays a key role in polyadenylation-
CC dependent pre-mRNA 3'-end formation and cooperates with cleavage
CC factors including the CFIA complex and NAB4/CFIB. Involved in poly(A)
CC site recognition. May be involved in coupling transcription termination
CC and mRNA 3'-end formation. {ECO:0000256|ARBA:ARBA00037232}.
CC -!- SIMILARITY: Belongs to the CFT1 family.
CC {ECO:0000256|ARBA:ARBA00038304}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV878126; OJI97734.1; -; Genomic_DNA.
DR STRING; 1036611.A0A1L9P8G8; -.
DR VEuPathDB; FungiDB:ASPVEDRAFT_126107; -.
DR OrthoDB; 149432at2759; -.
DR Proteomes; UP000184073; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 1.10.150.910; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR10644:SF2; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 1; 1.
DR PANTHER; PTHR10644; DNA REPAIR/RNA PROCESSING CPSF FAMILY; 1.
DR Pfam; PF03178; CPSF_A; 1.
DR Pfam; PF10433; MMS1_N; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000184073}.
FT DOMAIN 94..704
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10433"
FT DOMAIN 1003..1344
FT /note="Cleavage/polyadenylation specificity factor A
FT subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03178"
SQ SEQUENCE 1379 AA; 150925 MW; 1A25506A05E0DDEB CRC64;
MQCYTELLPP TGITHALAIP FLSSTASNLV VVRTSLFQIF SLCTVQSGSD DPREWPTQKV
QDTHKLVLER EYQLPGTVTD LCRVKILNTK SGGDAILLAS RDSKLSLIEW DPGRHGISTV
SIHYYERDDT TISPWVSDLG SCGSMLSADP SSRCAVFQFG ARNLAIIPFH QPGDDLVMDD
YGSEFGDHNK SDGNSKARDE AKAESDIAYQ TPYASSFVLP LTALDPSVLH PISLAFLYEY
REPTFGILYS QVATSDALLH ERKDVVFYTV FTLDLEQRAS TTLLSVPRLP SDVFKVVALP
PPVGGSLLIG SNELVHVDQA GKTNAVGVNE FSRQVSSFSM TDQSDLAIRL ENCVVERFIE
GNGDLLLALS TGEMALISFK LDGRSVSGLS VHLMSAQTDM FLASTTSCSA FLGHGKVFFG
SEDADSVLLS WSSMSSVTKK SKSHARHSIS GDFSDDDYQS EDDAYEDDLY SSAPDRTTDN
RQEVPVSLSA VGLGDLRIHD KLFSSGPIND VVLGKSSEVS PNSDGVAKTA LSELELVAAQ
GSDGGGALVI MKREIDPYIV ASMATDSADS LWTVSLTQAP ADNGNLKQHD YVILSKQESN
DREESEVFIL ENKLRPFTAP EFNPNHDLTI EIGTLKTKNR VIQVLRNEVR SYDAGLGLVQ
IYPVWDEDNS DERVALGASL ADPYLAIIRD DSSLLLLQAD DSGDLDEMTV AEDAASQRWL
SACLYADRTG FFSNSKSHRG NLDPQNIFLF LLNQDHQLYI YRLPDLKLMT TIEGVGCLSP
ILSTEPPKRS TTRENLIQLV VADLGDSYYC LPYLILRTGN DDLVVYKPFL TDSPSEELAG
LSFLKEANHV LPKIPTTSDG WQSEPRPLRV LPNISGCSGV FIPGSSAGFV FRTSATAPHF
IRLRGDYTKG LGCFSSPDKG FAYLDSNGLA HLATLPHGAQ LGYSWTFKRV PIGEQIDQLT
YSSTSSTYVL GTCHRSGFKL PDDDELHPEW RNEVVSFLPE VHQSSLKVVS PKTWTVIDSY
PLEPAEHIMA LKTMSLEVSE NTHERRDMIV VGTSLARGED IPSRGCIYVF EVIKVVSDPD
QPQANHRLKL IGKEPVKGAV TALSEIGSQG FLIAAQGQKS MVRGLKEDGS LLPVAFMDMQ
CYVSVVKELR GTGMCILGDA VKGLWFAGYS EEPYKMSLFA KDLDYLEVVA ADFLPDNNKL
FIIVADSDCN IYVLQYDPED PNSSNGDKLL NRSKFHTGNF ASSVTLLPRT LVSSERVMSG
SDDMDMDSVA PLHHALVTSH NGSIGLVTGV SEESYRRLSA LQSQLTNTLE HPCGLNPRAY
RAVESDASAG RGMLDGNLLF QYLDMSKQRK VEIAGRVGAK EWEIKADLEV IGGDGLGYL
//
