ID A0A1L9PZ76_ASPVE Unreviewed; 1423 AA.
AC A0A1L9PZ76;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN ORFNames=ASPVEDRAFT_140203 {ECO:0000313|EMBL:OJJ06837.1};
OS Aspergillus versicolor CBS 583.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=1036611 {ECO:0000313|EMBL:OJJ06837.1, ECO:0000313|Proteomes:UP000184073};
RN [1] {ECO:0000313|Proteomes:UP000184073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 583.65 {ECO:0000313|Proteomes:UP000184073};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC the other cwf proteins as part of the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SIMILARITY: Belongs to the CWF11 family.
CC {ECO:0000256|PIRNR:PIRNR038901}.
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DR EMBL; KV878135; OJJ06837.1; -; Genomic_DNA.
DR STRING; 1036611.A0A1L9PZ76; -.
DR VEuPathDB; FungiDB:ASPVEDRAFT_140203; -.
DR OrthoDB; 7041at2759; -.
DR Proteomes; UP000184073; Unassembled WGS sequence.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd17935; EEXXQc_AQR; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR048967; Aquarius_insert.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR026300; CWF11_fam.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR Pfam; PF21144; Aquarius_N_3rd; 1.
DR PIRSF; PIRSF038901; AQR_cwf11; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038901};
KW Reference proteome {ECO:0000313|Proteomes:UP000184073}.
FT DOMAIN 28..412
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 491..660
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 708..800
FT /note="RNA helicase aquarius insertion"
FT /evidence="ECO:0000259|Pfam:PF21144"
FT DOMAIN 812..1109
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1120..1311
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1423 AA; 161857 MW; 7B40990A42DFD96D CRC64;
MGLQTQHAMA SGLDSRPTVE DFRDDSPWVR LAKTHWLDAA NVRKVKHDVI KKDIWDPLEA
ENFSFRSLLT LENLNILEKF LWPTYTEDAS NYHVLLLTLI VSVKQREHLP IWEIFSDRPD
VFSNLFHRIL SMSIDQSLPS SSRISILSFM ISAFQSLENA LIRKECAPLV SISIWHNLHS
EEARERVLAK APSLKKAWRA STKRYEAGDE ATKTRMRFER SWLYTMLLDF LRRLNGSEKD
ERDDLRYCER FLEFLVDLES QLPTRRYVNT LLKDLHLLPI LRLSQLYRSA ENALFRDFYN
LLKHFATFAI NDYTGEALSA QAMYDSHCHD LAQLQRTSMK HFRDKLTILA LSNYGSIEQR
SELEGQLSSL DDSELQILCS RLGFRTNYPK QANVASDRHF YMEVLLSYHE RTTSFQEAAS
NLSVVPTEEN LYDPSLLRNE TYDGSRPLAI PKLNLQYLSL GDFLWRSFLL YRAEAFFQIR
KDMESIIKRM QPRSSQDGKT LVFEGFSRMA IPIAKPAIIE VAPPKVGSDK PAFVRAEITI
EVGRLADHIR TEWDSLRPDD VVFLLAVQPG NPGKFGLKDS NAAQTPGIIH LRSADVVQVL
DEAGRPLRDP SSSQANGYRS RPRVRRLLVN LDPVAFKGDK DRILQEKPDV YPLINVVARR
RGRENNFKSI LETMQRLIVS DITLPPWIQD IFLGYGDPAG ARFTELPNRL KSVDFRDTFL
DWQHLIESFP GLTIEPSGDA TSSFPPPYAL EYIEEPTQLP VSGASKKRRR DQFVEAQAAP
KSLRVSTYKP PNPGPYPVDA PKLNTVRFTP AQIDAIASGT QPGLTVIIGP PGTGKTDVVT
QIINNIYHNF PHERTLLVAH SNQALNQLFQ KIVALDIDER HLLRLGHGEE ELETESSYSK
YGRVESFLDN RNYFLAEVTR LAASIGAQGA HGNSCETAGY FNTVYVKPAW AKYWDSARAD
NASTEEIIAT FPFHEYFSNA PAPVFDPSAP KEALIDVAEG CERHIDKIFS ELEDIRPFEI
LKQPKDKANY LLVKEARIIA MTSTHAAMRR QEIADLGFHY DNVVMEEAAQ VTEIESFVPA
ALQNMKEGQL PLKRVVLCGD HLQNSPIIQN MAFRQYAHFE QSLFLRLVRL GVPAITLDQQ
GRARPSIAEL FRWRYQNLGN LPIVDEAQEF KQANAGFKYE YQLINVPDYQ GSGEREPTPH
FIQNLGEAEY AVAIFQFMRL LGYPASKISI LATYAGQTAL IKDVLNHRCA KNTLFGMPKI
VTTVDRYQGE QNDYVILSLT RTRTVGYLRD VRRLTVALSR ARLGLYVLGR REVFESCYEL
KPAFDLLLQR PDKLMLAPGE MFPATRTLDD DVQGSPMEGV EHLGQYVFEM TQAKIKAMDG
QDAVVDEEMP DEEGDLVAED GDEVMLGAGE EGEEDPLHEH VYT
//
