ID A0A1L9RAY6_ASPWE Unreviewed; 1315 AA.
AC A0A1L9RAY6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 13-SEP-2023, entry version 23.
DE RecName: Full=REM-1 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPWEDRAFT_31034 {ECO:0000313|EMBL:OJJ32096.1};
OS Aspergillus wentii DTO 134E9.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Cremei.
OX NCBI_TaxID=1073089 {ECO:0000313|EMBL:OJJ32096.1, ECO:0000313|Proteomes:UP000184383};
RN [1] {ECO:0000313|Proteomes:UP000184383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DTO 134E9 {ECO:0000313|Proteomes:UP000184383};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SIMILARITY: Belongs to the RICTOR family.
CC {ECO:0000256|ARBA:ARBA00008878}.
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DR EMBL; KV878215; OJJ32096.1; -; Genomic_DNA.
DR STRING; 1073089.A0A1L9RAY6; -.
DR VEuPathDB; FungiDB:ASPWEDRAFT_31034; -.
DR OrthoDB; 90320at2759; -.
DR Proteomes; UP000184383; Unassembled WGS sequence.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.10.287.160; HR1 repeat; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036274; HR1_rpt_sf.
DR InterPro; IPR028268; Pianissimo_fam.
DR InterPro; IPR028267; Pianissimo_N.
DR InterPro; IPR029453; Rictor_IV.
DR InterPro; IPR029451; RICTOR_M.
DR InterPro; IPR029452; RICTOR_V.
DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR Pfam; PF02185; HR1; 1.
DR Pfam; PF14663; RasGEF_N_2; 1.
DR Pfam; PF14666; RICTOR_M; 1.
DR Pfam; PF14664; RICTOR_N; 1.
DR Pfam; PF14668; RICTOR_V; 1.
DR SMART; SM00742; Hr1; 1.
DR SMART; SM01303; RasGEF_N_2; 1.
DR SMART; SM01307; RICTOR_M; 1.
DR SMART; SM01308; RICTOR_N; 1.
DR SMART; SM01310; RICTOR_V; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF46585; HR1 repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000184383}.
FT DOMAIN 116..184
FT /note="REM-1"
FT /evidence="ECO:0000259|SMART:SM00742"
FT DOMAIN 250..614
FT /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01308"
FT DOMAIN 693..917
FT /note="Rapamycin-insensitive companion of mTOR middle"
FT /evidence="ECO:0000259|SMART:SM01307"
FT DOMAIN 1100..1171
FT /note="Rapamycin-insensitive companion of mTOR"
FT /evidence="ECO:0000259|SMART:SM01310"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1315 AA; 146689 MW; CF57C13A28B127B9 CRC64;
MASGYNSGFS GTSTQHRVLG DGRTSHDDGS ADGSWVDSAS RIGRNGRSES GGSSIIGPRV
GSGGSLAPSI GGPGSFSSEL KSMTSRSVTP RPDGTFPRRP SSSNVDQDTD LLGTDERQAA
LRDRIAKEMK IKMGTENMLE ALLSKPKHAK DQRLKVESEL GSSNRKLAEL QHELEEELLR
AQAPSTPPRT RLSSTVFRSS PMRSPSRTND HVDDGPLVEE GEGEIESPTY VLAETLQALE
IEGMSPDFYV ERANSLVELF KRHPTLKYDL EWSVFGLRVQ VMLLGDSKEV VAAGYRLTRY
AIADRKSLQT IRSLHTDELV ILSLVKESKA SIEREQALKF VRGFLDVKDG VQEISRAVVR
TIVAVAEHHE DRLRNISIMT LAEILVKDPE LIAYAGGFGT LHDALAEGTF GASESLISSF
LHVLDTPHSR KHLQGGCELE AVLAPFTDSL SDSVRNGRLK SAAKAISAML KTWPGLVVLA
RHETKPLHSL LESLHYQDPQ ARDLIMELLF DALRIKPPSW SSSFFAGRRL TTYGRVANLR
PETDTKQYRG FYDDNSNKFD LTAHFSTLVL ATLVEAGLSK ALSDLIEDEI DLFLRRKATL
LLTEVLKLAH HSLPQSISAN LQVLPHLLPA AVKFDVDNHD ISTSTIYQIE SINRTLARSI
GFSNGAARYS VDADISASIL SNDQGKDKLS PTMDETQFRN AILETNVLNT VNYIKWKWDL
IHRIVEGPLI NPKRLDEAIK GSKFVKRLIG FYRPFKYRFS MISNTKINQR YVRTGCALMR
TLVQNPEGTK YLAENKFLRQ VAECLAQVDR MSGLTSSSPL FSREQMANTL SGGYFAMLGT
LSGDSNGLAM MERWHMLNMF YHIIELRDRN DLIQTLLGNM DYAHESHLRV MLSKALTTGS
KEIRIFSTRL LWKYAVGDGT LSPSMAISNA DWVIKLLVTQ LYDPDVSVCQ VAVKILEEAC
NKRDYLEFVV KCRPSLDHLG EIGAPLLLRF LSTSVGYHYL DGLDYITQEM DDWFLGRNDA
YVGLVEAALS RAYVDQPRRS SFAPEDLVDM QDIGLVPPHF YRELARTAEG CSLLEQSGHF
NEFAWTVRDF QLNEEDNESL LKVKGCLWAV GNVGSMELGA PFLEKDLVEH IVKIAESAEV
LTMRGTAFFV LGLISRSRHG LKVLRSVGWD SAVDQKGDSL GFCLPTDFNK LFLVEFPAHG
RSPDAKRNSR DKFKAATMDP DPVNQKILKL VVDMGNTVLS KRAAADLHSI KSKQPERFHQ
SQLFRKALCI LEGHHFRLPA RRYAFDLFDK SVMRRIVLEE DSDTESETTS SQESG
//
