ID A0A1L9S950_9EURO Unreviewed; 1503 AA.
AC A0A1L9S950;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=ASPZODRAFT_19408 {ECO:0000313|EMBL:OJJ43691.1};
OS Penicilliopsis zonata CBS 506.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicilliopsis.
OX NCBI_TaxID=1073090 {ECO:0000313|EMBL:OJJ43691.1, ECO:0000313|Proteomes:UP000184188};
RN [1] {ECO:0000313|Proteomes:UP000184188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 506.65 {ECO:0000313|Proteomes:UP000184188};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000256|ARBA:ARBA00008251}.
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DR EMBL; KV878351; OJJ43691.1; -; Genomic_DNA.
DR STRING; 1073090.A0A1L9S950; -.
DR VEuPathDB; FungiDB:ASPZODRAFT_19408; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000184188; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF50939; Sialidases; 2.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000184188};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1503
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012566917"
FT TRANSMEM 1371..1392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1422..1448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..679
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 720..1360
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 662..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1503 AA; 167415 MW; BDB1ABDAB91305A8 CRC64;
MIPRWLLLIS VLLLALLSQP GAAKKSGGPR ITETKLDHDP NNLFYFEDSD NVLYIESITR
HVRCSFDAGE TWAVVKTPDG GDNIKAFNLW QHPYDRNKAY ILGEAGTHWI TTDQAKTWTS
FKIDMIPSMI HLPMSFHGWD SSKVIIQGEQ CAGFHCKETS YYTVDDFKTV APLRDGIFAC
SWAVGSPEFA KDLGVAAEIG NRVLCIVPGL KPLFGGGSRL VYSDSFFGKD GDEDGVEVKL
QAGRPVSGIL NTAAVKKFLL VAARSQGTDE LALYVSDDAR VWHRAEFGNH RLEEDAYTIL
ESTNYSIQVD VLTTGRDKGM GVLFTSNSNG TYFTRNIEHT NRNPMGLVDF EKIANIQGIV
LVNAVDNWEA VEKDSREPKK VVSRISFDDG RTFQPLTMGD KKLNLHSVTA FANVGRVFSS
PAPGLVMGVG NTGSHLEDYL KGDLFVSDDA GVTWRKALDG SHKYEFGDQG AVIIAVEDDG
KTDKIRYSID HGKEWETAEL PQKIYPRLLT TTPDSTSLKF LLVGSTSNDN SQDTVSIYSI
DFNGLHERKC EKDDFEKWPA RLDEKGEPDC LMGHKQYYRR RKANADCFID EEFKNPDPIF
EPCKCTADDF ECDYNFVRSE DRKSCVPAVA LAAPEGQCRN PDDTYMGPSG WRLIPGNACQ
RDGGEKLDDN VKRPCGDTTG GGQPSADGPV STSKQFFDSA STYDEYYYLE RQASSSGTDE
TILMRTRNDE LYVSHDHGET WQQPVKGEKI VQVIPHPYYS DGAFFLTDGK KGYWTVDRVQ
SPLKSFETPA LPNQEQLPVL IFHPKYKDWL IWTGAVDCNT AQCHSNAWIS KNRGESWELL
LRYVRKCEFV YREDRVDSAD LVFCEQFENE NQKNPLQLLS SKSWFTESDV HFKDVIDFAS
MAEFIVVAAR DKDNRESLKA STSVDGSVFA AAEFPANLQV PVQKAYTVLD SSTHAVFLHV
TVNNAANTAY GSLVKSNSNG TSYVLSLNGV NRNDLGYVDF EKMQGLEGVA VVNTVGNLVA
IESGKANQKK LKTMITHNDG AQWALLPPPA KDANNKNFGC SVKDNKPTDK CALHLHGYTE
RRDPRDTYSS GSAIGLMMGV GNVGEYLSAN MDDADTFLTR DGGITWKAVK KGRYMWEYGD
AGSVIVIVPD STPTKSLFYS TNEGDSWTEF QFSDVQMEIT DISTLPSDTS KKFLLWGREV
DSDRSNKLST VSLDFSGLRD KSCQLNEDLG ENEDYYLWKP RHPLQDNNCL FGHIEQYHRR
KPTAECWNDW REPHVHSIGM NCTCTRADYE CDYNYEPQSD GSCALVPGLP KPNAMAVCKS
NPDQIEYWEP TGYRRIPLTT CQGGLALDRI VSRPCPDHEQ EYEEKHGISG VGLFFAIVIP
VAVAGAVGYW AYTRWDGKFG QIRLGENVGV ATGGLLSRDS PFVAVPVVII AGVVAVAQAL
PLLVVSLWRS ASGYLHIGRD RGYARPYASR RSFAARRGDY TSVVDDEDEL LGADDLEDDE
DEV
//
