ID A0A1L9SSK2_9EURO Unreviewed; 999 AA.
AC A0A1L9SSK2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Rad4 beta-hairpin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPZODRAFT_139503 {ECO:0000313|EMBL:OJJ50185.1};
OS Penicilliopsis zonata CBS 506.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicilliopsis.
OX NCBI_TaxID=1073090 {ECO:0000313|EMBL:OJJ50185.1, ECO:0000313|Proteomes:UP000184188};
RN [1] {ECO:0000313|Proteomes:UP000184188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 506.65 {ECO:0000313|Proteomes:UP000184188};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; KV878337; OJJ50185.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9SSK2; -.
DR STRING; 1073090.A0A1L9SSK2; -.
DR VEuPathDB; FungiDB:ASPZODRAFT_139503; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000184188; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.60.290; Rad4, beta-hairpin domain BHD2; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF3; DNA REPAIR PROTEIN RAD4; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000184188}.
FT DOMAIN 517..577
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 579..639
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 646..720
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..999
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 999 AA; 111147 MW; 89821D95101A6131 CRC64;
MVRRLQRARP GRGGGTRRSQ PRRGHDDNEI PEAYLEMLVE AESRDSTSLE TDRPIKRRKV
GERVRPAALT APLLDDTPTT NAQIVSLPDE SGSDDETRQV QTAYDSTASE EDSDEEEMDW
EEVDIQQAPI PVAASSDEYF QPAGSGRTGD ESLQITLEKP STARKAAVPR RRPLSAAEKK
LRLEIHKVHL LCLLSHVNRR NIWCNDEEVQ GFLKQMLPKQ IISLLNPPEN RPQPSRSAVF
IDGLNQAADV FSKRFRKTMP GLKRPHWQDE PEAVQDRAKS IMSDAEVFLS RDDFRKQAKS
LRGSRDFGAQ LFCALLRSVA VEARLVCSLQ PLTFSGAIKN TTTPKKQRSS YIVISSDESH
ETSSSEKQSP LPTRRLGRPQ FTSKRPLQAS SRLDRPPRLS ESSYPVFWVE AFNEVVQKWI
PIDPLVTMSL AKPSKFEPPA SDPHNQMSYV VAFEDDGSAR DVTRRYAKAF NAKTRKLRVE
STRNGEMWWT RTLRAFEKPF LEDRDEIEVS ELTARTAAEP MPRNVQDFKD HPVYALDRHL
RRNQVVHPKR VIGQVSLGKS GMKNEVLEPV YRRSDVHNLR SADGWYRLGR DIKLGEQALK
RVRPSRNRVA ETTDGEGGDD PVEMTPLYAS FQTEVYQPPP VIKGRIPKNG YGNLDVYVPS
MVPPGGVHVK HLEARQAARI LGIDYADAVT GFNFKGRHGT AVFEGVVIAA EYLEAVQEVL
RGLEHERVHA ELELRSAAAL QMWKHLLLRL RIAERVKGYA VEGEDEENIS DAVDEAGAEE
DADEDVEVAG GGFLLESHIE EASGGGFLPE PLDRDSGGVL SSGLVHETQS SRHSHPPDED
EDDFGGGFIP EDESVQSASI IQPLPPIPPQ STLRREQADN QPRYSLVVVP NEQPNHSSGS
ELHHAKPSTP SVESPDPGPQ VDPPTRDTVD GSSEVPIVVS SSVGGDSKSV SLEVVSRSPP
GMHSPVDDVE EPGSQVDEVS LLSEDPDDED AIPEWLMSD
//
