ID A0A1L9T2Z0_9EURO Unreviewed; 899 AA.
AC A0A1L9T2Z0;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Mechanosensitive ion channel protein {ECO:0000256|PIRNR:PIRNR017209};
GN ORFNames=ASPSYDRAFT_50559 {ECO:0000313|EMBL:OJJ53810.1};
OS Aspergillus sydowii CBS 593.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=1036612 {ECO:0000313|EMBL:OJJ53810.1, ECO:0000313|Proteomes:UP000184356};
RN [1] {ECO:0000313|Proteomes:UP000184356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 593.65 {ECO:0000313|Proteomes:UP000184356};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|PIRNR:PIRNR017209}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|PIRNR:PIRNR017209}.
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DR EMBL; KV878596; OJJ53810.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1L9T2Z0; -.
DR STRING; 1036612.A0A1L9T2Z0; -.
DR VEuPathDB; FungiDB:ASPSYDRAFT_50559; -.
DR OrthoDB; 1362946at2759; -.
DR Proteomes; UP000184356; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR016688; MscS-like_plants/fungi.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR PANTHER; PTHR31323:SF15; MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1; 1.
DR PANTHER; PTHR31323; MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR PIRSF; PIRSF017209; Memb_At2g17000_prd; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR017209};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR017209};
KW Reference proteome {ECO:0000313|Proteomes:UP000184356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 426..461
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 899 AA; 100604 MW; 8EF26CCCA301FDAF CRC64;
MDEKDHDKKE HSSSDGTYVG EPSVSPSSHL KVDTNVNDVE PGPMSTASSR REQATRFDDD
LQLMQAERVV SQSTQAQSQH GATSMDRSRS HRSHVDEFDE ATNPLHEKTA VYTPPESPRT
KLSAFVKKVH ESSFIVRYLT YIVPVVLLLL IPLLVGALEY TDTDVGGVQL MWFAIWLEIV
WLTLWAARLV GKCIPPVVSI VASIFTNNAK KWRDMAKQLE VHFVLFFWWL AVEISFLPTM
KNHHVDGDKR TRGWEGTLNK LIIVGLVWTV LNLVEKFLIQ LIAMSFHRRT YDSRIQINKF
QIGSLSKLYQ FSRSRITEED EAFEQNNDNE KTPDNPRNPL QYATKAGRVA QKAAKTVGNK
VGDVAGGVVA DFTGKKGKSS SDPHQVILAL LRSPSGSQVL ARRLYRTFVR DGFDTVFSGD
LKEAFDDNEE AEAAFSMFDR DMNGDISMEE LEAVCVDIGR ERKSITASLK DLDSVVSKLD
QVFMFFVFII IVIVFLTLIS TSAAGVLTSA GSTILALSWM FSTTATEFLQ SIIFVFVKHP
FDVGDRVTIY GNAGDNGLGD DYFVKEIALL YTEFKKMQGH IVQAPNSVLN NLFILNQRRT
GPLAEALPIV IKYGTTVDQM ERLRQRLVEF VRSEKRDFQN MILTELREVT ENLSLTLNVV
FFYKSNWQNE LLRLQRRNKF ICMLMVALQE IGIEGPRMNL QGYTTSTPFH VAYSGAPPGG
APPPTYQDHD QDRSATTGEE HTGAGSEVRI DESQTIPENS GTSSGVQPRP SILRRGMDTA
AARSRGEPIS RNKHVDFSLG MSDISSNDIM GDVFEDRGST SGHVDEVVRN ANKQAADRRM
QEIAEEERHS TQEARSSADG RSVRSGTSSA RHRFGRRRGS VSRERGGDIE AGSARSVRE
//
