ID A0A1L9TFT9_9EURO Unreviewed; 1810 AA.
AC A0A1L9TFT9;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPSYDRAFT_1047256 {ECO:0000313|EMBL:OJJ58299.1};
OS Aspergillus sydowii CBS 593.65.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=1036612 {ECO:0000313|EMBL:OJJ58299.1, ECO:0000313|Proteomes:UP000184356};
RN [1] {ECO:0000313|Proteomes:UP000184356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 593.65 {ECO:0000313|Proteomes:UP000184356};
RX PubMed=28196534; DOI=10.1186/s13059-017-1151-0;
RA de Vries R.P., Riley R., Wiebenga A., Aguilar-Osorio G., Amillis S.,
RA Uchima C.A., Anderluh G., Asadollahi M., Askin M., Barry K., Battaglia E.,
RA Bayram O., Benocci T., Braus-Stromeyer S.A., Caldana C., Canovas D.,
RA Cerqueira G.C., Chen F., Chen W., Choi C., Clum A., Dos Santos R.A.,
RA Damasio A.R., Diallinas G., Emri T., Fekete E., Flipphi M., Freyberg S.,
RA Gallo A., Gournas C., Habgood R., Hainaut M., Harispe M.L., Henrissat B.,
RA Hilden K.S., Hope R., Hossain A., Karabika E., Karaffa L., Karanyi Z.,
RA Krasevec N., Kuo A., Kusch H., LaButti K., Lagendijk E.L., Lapidus A.,
RA Levasseur A., Lindquist E., Lipzen A., Logrieco A.F., MacCabe A.,
RA Maekelae M.R., Malavazi I., Melin P., Meyer V., Mielnichuk N., Miskei M.,
RA Molnar A.P., Mule G., Ngan C.Y., Orejas M., Orosz E., Ouedraogo J.P.,
RA Overkamp K.M., Park H.-S., Perrone G., Piumi F., Punt P.J., Ram A.F.,
RA Ramon A., Rauscher S., Record E., Riano-Pachon D.M., Robert V., Roehrig J.,
RA Ruller R., Salamov A., Salih N.S., Samson R.A., Sandor E., Sanguinetti M.,
RA Schuetze T., Sepcic K., Shelest E., Sherlock G., Sophianopoulou V.,
RA Squina F.M., Sun H., Susca A., Todd R.B., Tsang A., Unkles S.E.,
RA van de Wiele N., van Rossen-Uffink D., Oliveira J.V., Vesth T.C.,
RA Visser J., Yu J.-H., Zhou M., Andersen M.R., Archer D.B., Baker S.E.,
RA Benoit I., Brakhage A.A., Braus G.H., Fischer R., Frisvad J.C.,
RA Goldman G.H., Houbraken J., Oakley B., Pocsi I., Scazzocchio C.,
RA Seiboth B., vanKuyk P.A., Wortman J., Dyer P.S., Grigoriev I.V.;
RT "Comparative genomics reveals high biological diversity and specific
RT adaptations in the industrially and medically important fungal genus
RT Aspergillus.";
RL Genome Biol. 18:RESEARCH28.1-RESEARCH28.45(2017).
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DR EMBL; KV878587; OJJ58299.1; -; Genomic_DNA.
DR STRING; 1036612.A0A1L9TFT9; -.
DR VEuPathDB; FungiDB:ASPSYDRAFT_1047256; -.
DR OrthoDB; 2734900at2759; -.
DR Proteomes; UP000184356; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000184356};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 990..1182
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1219..1373
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1438..1750
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1753..1772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..235
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1810 AA; 200388 MW; 3832CDBBFA9B34A4 CRC64;
MANYHNGNHY YGQSGDQQRY EPYTPPSTNP PLRRMPSYDA GDDASLFAPS THNLRPVETN
HRYGHAGTGE HPGTHSLAAA VRDDYADPRY SQIPSATSPP RARAQTQSGY PQYQYTSSEN
PMSPTQTSYN PQQYALPATT SQQHTGYSPL SYTSSVSYGH HNNNSSSSTS PTHQPYNPAA
YQATNIGTLG SPTIHRQPSV SFAQTPLSPH PYGSSHPSLP PPPPPRGPDH PYGSRPTPPY
SSASPGTQFG FQSQHSSQSS VATSSYSLAS PTTPTTAYTS GGSLSSMASY NSRTYAGGVP
IPSHISHPSR LSDPGRAPPV AEEPPEPPAH LYGDNYDKPY SPLRPSGRSL PTPPLHQGQP
PRRTDTLTRH PQARPLPGPP VESDQGQQSG GYTNGAAGNP SAGYTDLVNQ VEAAIPENQW
SNDYQPTQRP LHIDIHNQVD RSGSTDSAHP SGSDLVHLSP DERHTHTNGS VAITTGQYVN
YDAYSDDSDA EAEAGVAWLR MADEEERAQA ERLQERTRRE SAVPPTSTLP QRSSVSASSP
AQTTRAEWYP PHGGEGYSRH SSHDDTAPRI SPYGEDSDYV NHHPVTTSGS RHSSNTSGEE
RAEYSDEYDY PPIEDDYAFP FPQLPSSARV DAGGTGGLSE PSAHNRRMSF DYGDETDGSL
SHRRQSHHSG SEGSFGENEP GDLFFHPGMR PLPPPPQEPV DNATLIPHLL PAGTYRHQDS
GDIPQYSPSY IPAPSPDAYS VTAPSPTQFS RSTSLTTHPI GPRADPPIRS KTDADKAKYR
QQQEMLRQGL LKLDPSMDTA AAAIPLDLPI IPAGRRKKFH PAKLSSEDFR RCEEPWALSA
VLAWIRELTE DETDLKEHAV VDAIVALFTH KVPTMNIADA ETLAARVVQN MLDQGALVKD
EEWVKFGNGM VLSGVLFQIT GTGCYSPVLH EQETEGEVVG RCYSHHCMRT LRKVNLRAQL
MEPEKKVEDW VTFYKVSKEI LEGHPKKEID RQNNLHEIVT TEDSFIGQLD VLRELYRDRL
AHSEPSIIPP KRASKFLNDV FGKVDAVKRV NEDYLLAQLK YRQKEQGPFI AGFSDIFREW
IRKAKAVYIS YAETFPHANY LIRKEAERNV VFRQFLSTAR DHKLSNRLSW DTFLKAPITR
IQRYTLLLST VHRNMLKDSE EKTNLAQAIE EIKIVALECD NKVGEMSKKV DLRELATKLQ
LRPDMRKRVE LNLDFLGREV VFRGDLQRPG SRTRFLVDTH AILFDHFLVL AKSSITKDTA
RTIKYESYDV SKLPIPMDLL VLESTREEPV VKSAVRGVVA AAPGAQPGGL AHNNADTSGK
TFVPTTVLEN SKDDKVLYPF KVKHLGLNET YILYAPSPQN RKDWCDKITE AKTKHAASLY
AQNAEPFRLR VLSDTAFASS DSSPPPSGAV IKGTPLDRAV RDVEKSYPVS SRPSPICRAA
VHCATVFEQP AGHKMCAIGT DYGVYVSEYN NPRGWSRAIA MARVTQIAVF EEFNVFLLIA
DRSLIAYHLD VVCPATGMNN QTTSDSARRA PQKLSGNREV GFFAAGHMKD RTLVMYKKRD
GLSSTYKILE PVLQKSATSR SRFFSTRRSQ TEFFREYDEF YIPAESYGMN LFHSSLAIST
QKGIEILTLD KKQTWSVPEF RTEAQEAQTH LNEISRRITG LRPLGMFRLS DAEFLVTYTE
CAVYVNQHGD VSRSVVLEFV GRAHSACLYG KFLILFNEDF VEVRNAMNGR LRQVIPGHNV
VCLDDGSRFP GSGANSIPTS SGDTVNLSSG SSNGASLANQ GRTVKICMQH PDHPRNLLVL
ELIENEGSKD
//
